Disseminated tuberculosis in rare association with hemophagocytic lymphocytosis - A case report from central India

Hemophagocytic Lymphohistiocytosis (HLH) is an uncommon, diverse and rare genetic hyper-inflammatory syndrome. HLH associated with tuberculosis (TB-HLH) has been described as a clinical and diagnostic quandary. The co-existence leads to significantly higher morbidity and mortality. Our case highligh...

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Detalles Bibliográficos
Autores principales: Gautam, Disha, Dadheech, Malti, Ingle, Vaibhav, Jayashankar, Erukkambattu, Purwar, Shashank, Maurya, Anand Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161793/
https://www.ncbi.nlm.nih.gov/pubmed/37151652
http://dx.doi.org/10.1016/j.heliyon.2023.e15646
Descripción
Sumario:Hemophagocytic Lymphohistiocytosis (HLH) is an uncommon, diverse and rare genetic hyper-inflammatory syndrome. HLH associated with tuberculosis (TB-HLH) has been described as a clinical and diagnostic quandary. The co-existence leads to significantly higher morbidity and mortality. Our case highlights the presence of disseminated tuberculosis and worsening of the case due to underlying hemophagocytic syndrome leading to rapid deterioration of patient prognosis. Prompt diagnosis and treatment remains help to improve patient management.

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