Innate immune cell genetic risk factors are linked to COVID-19 severity

Single-cell RNA-sequencing analysis combined with host genetic data for a Japanese population reveals the dysfunction of innate immune cells, particularly non-classical monocytes, in individuals with severe COVID-19, as well as enrichment of host genetic risk factors for severe COVID-19 in monocytes...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Research Briefing
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161972/
https://www.ncbi.nlm.nih.gov/pubmed/37147488
http://dx.doi.org/10.1038/s41588-023-01378-y
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description Single-cell RNA-sequencing analysis combined with host genetic data for a Japanese population reveals the dysfunction of innate immune cells, particularly non-classical monocytes, in individuals with severe COVID-19, as well as enrichment of host genetic risk factors for severe COVID-19 in monocytes and dendritic cells.
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spelling pubmed-101619722023-05-09 Innate immune cell genetic risk factors are linked to COVID-19 severity Nat Genet Research Briefing Single-cell RNA-sequencing analysis combined with host genetic data for a Japanese population reveals the dysfunction of innate immune cells, particularly non-classical monocytes, in individuals with severe COVID-19, as well as enrichment of host genetic risk factors for severe COVID-19 in monocytes and dendritic cells. Nature Publishing Group US 2023-05-05 2023 /pmc/articles/PMC10161972/ /pubmed/37147488 http://dx.doi.org/10.1038/s41588-023-01378-y Text en © Springer Nature America, Inc. 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Briefing
Innate immune cell genetic risk factors are linked to COVID-19 severity
title Innate immune cell genetic risk factors are linked to COVID-19 severity
title_full Innate immune cell genetic risk factors are linked to COVID-19 severity
title_fullStr Innate immune cell genetic risk factors are linked to COVID-19 severity
title_full_unstemmed Innate immune cell genetic risk factors are linked to COVID-19 severity
title_short Innate immune cell genetic risk factors are linked to COVID-19 severity
title_sort innate immune cell genetic risk factors are linked to covid-19 severity
topic Research Briefing
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161972/
https://www.ncbi.nlm.nih.gov/pubmed/37147488
http://dx.doi.org/10.1038/s41588-023-01378-y

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