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Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models

Ubiquitin proteasome activity is suppressed in enzalutamide resistant prostate cancer cells, and the heat shock protein 70/STIP1 homology and U-box-containing protein 1 (HSP70/STUB1) machinery are involved in androgen receptor (AR) and AR variant protein stabilization. Targeting HSP70 could be a via...

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Detalles Bibliográficos
Autores principales:	Xu, Pengfei, Yang, Joy C., Ning, Shu, Chen, Bo, Nip, Christopher, Wei, Qiang, Liu, Liangren, Johnson, Oleta T., Gao, Allen C., Gestwicki, Jason E., Evans, Christopher P., Liu, Chengfei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162009/ https://www.ncbi.nlm.nih.gov/pubmed/36773708 http://dx.doi.org/10.1016/j.phrs.2023.106692

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