Dysregulation of the chromatin environment leads to differential alternative splicing as a mechanism of disease in a human model of autism spectrum disorder

Autism spectrum disorder (ASD) affects 1 in 44 children. Chromatin regulatory proteins are overrepresented among genes that contain high risk variants in ASD. Disruption of the chromatin environment leads to widespread dysregulation of gene expression, which is traditionally thought of as a mechanis...

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Detalles Bibliográficos
Autores principales: Leung, Calvin S, Rosenzweig, Shoshana J, Yoon, Brian, Marinelli, Nicholas A, Hollingsworth, Ethan W, Maguire, Abbie M, Cowen, Mara H, Schmidt, Michael, Imitola, Jaime, Gamsiz Uzun, Ece D, Lizarraga, Sofia B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162432/
https://www.ncbi.nlm.nih.gov/pubmed/36621967
http://dx.doi.org/10.1093/hmg/ddad002

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