Mitotic CDK1 and 4E-BP1 I: Loss of 4E-BP1 serine 82 phosphorylation promotes proliferative polycystic disease and lymphoma in aged or sublethally irradiated mice

4E-BP1 is a tumor suppressor regulating cap-dependent translation that is in turn controlled by mechanistic target of rapamycin (mTOR) or cyclin-dependent kinase 1 (CDK1) phosphorylation. 4E-BP1 serine 82 (S82) is phosphorylated by CDK1, but not mTOR, and the consequences of this mitosis-specific ph...

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Detalles Bibliográficos
Autores principales: Sun, Rui, Guo, Siying, Shuda, Yoko, Chakka, Anish B., Rigatti, Lora H., Zhao, Guangyi, Ali, Mohammed A. E., Park, Christopher Y., Chandran, Uma, Yu, Jian, Bakkenist, Christopher J., Shuda, Masahiro, Moore, Patrick S., Chang, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162543/
https://www.ncbi.nlm.nih.gov/pubmed/37145994
http://dx.doi.org/10.1371/journal.pone.0282722

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