m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis

N6-methyladenosine (m6A) is the most pervasive RNA modification in eukaryotic cells. The dynamic and reversible m6A modification of RNA plays a critical role in the occurrence and progression of tumors by regulating RNA metabolism, including translocation, mRNA stability or decay, pre-mRNA splicing,...

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Autores principales: Jiang, Xiaohan, Jin, Ziyao, Yang, Yuzhong, Zheng, Xiang, Chen, Shaohua, Wang, Shuaijie, Zhang, Xuemei, Qu, Nanfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162644/
https://www.ncbi.nlm.nih.gov/pubmed/37152066
http://dx.doi.org/10.3389/fonc.2023.1162300
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author Jiang, Xiaohan
Jin, Ziyao
Yang, Yuzhong
Zheng, Xiang
Chen, Shaohua
Wang, Shuaijie
Zhang, Xuemei
Qu, Nanfang
author_facet Jiang, Xiaohan
Jin, Ziyao
Yang, Yuzhong
Zheng, Xiang
Chen, Shaohua
Wang, Shuaijie
Zhang, Xuemei
Qu, Nanfang
author_sort Jiang, Xiaohan
collection PubMed
description N6-methyladenosine (m6A) is the most pervasive RNA modification in eukaryotic cells. The dynamic and reversible m6A modification of RNA plays a critical role in the occurrence and progression of tumors by regulating RNA metabolism, including translocation, mRNA stability or decay, pre-mRNA splicing, and lncRNA processing. Numerous studies have shown that m6A modification is involved in the development of various cancers. This review aims to summarize the significant role of m6A modification in the proliferation and tumorigenesis of CRC, as well as the potential of modulating m6A modification for tumor treatment. These findings may offer new therapeutic strategies for clinical implementation of m6A modification in CRC in the near future.
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spelling pubmed-101626442023-05-06 m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis Jiang, Xiaohan Jin, Ziyao Yang, Yuzhong Zheng, Xiang Chen, Shaohua Wang, Shuaijie Zhang, Xuemei Qu, Nanfang Front Oncol Oncology N6-methyladenosine (m6A) is the most pervasive RNA modification in eukaryotic cells. The dynamic and reversible m6A modification of RNA plays a critical role in the occurrence and progression of tumors by regulating RNA metabolism, including translocation, mRNA stability or decay, pre-mRNA splicing, and lncRNA processing. Numerous studies have shown that m6A modification is involved in the development of various cancers. This review aims to summarize the significant role of m6A modification in the proliferation and tumorigenesis of CRC, as well as the potential of modulating m6A modification for tumor treatment. These findings may offer new therapeutic strategies for clinical implementation of m6A modification in CRC in the near future. Frontiers Media S.A. 2023-04-21 /pmc/articles/PMC10162644/ /pubmed/37152066 http://dx.doi.org/10.3389/fonc.2023.1162300 Text en Copyright © 2023 Jiang, Jin, Yang, Zheng, Chen, Wang, Zhang and Qu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Jiang, Xiaohan
Jin, Ziyao
Yang, Yuzhong
Zheng, Xiang
Chen, Shaohua
Wang, Shuaijie
Zhang, Xuemei
Qu, Nanfang
m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis
title m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis
title_full m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis
title_fullStr m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis
title_full_unstemmed m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis
title_short m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis
title_sort m6a modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162644/
https://www.ncbi.nlm.nih.gov/pubmed/37152066
http://dx.doi.org/10.3389/fonc.2023.1162300
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