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Entropic contribution of ACE2 glycans to RBD binding

The spike protein of the SARS-CoV-2 virus (the causative agent of COVID-19) recognizes the host cell by binding to the peptidase domain (PD) of the extracellular receptor angiotensin-converting enzyme 2 (ACE2). A variety of carbohydrates could be attached to the six asparagines in the PD, resulting...

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Detalles Bibliográficos
Autores principales: Mugnai, Mauro L., Shin, Sucheol, Thirumalai, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162944/
https://www.ncbi.nlm.nih.gov/pubmed/37149733
http://dx.doi.org/10.1016/j.bpj.2023.05.003