A Cas12a ortholog with distinct TTNA PAM enables sensitive detection of HPV16/18

CRISPR-associated (Cas) nucleases are multifunctional tools for gene editing. Cas12a possesses several advantages, including the requirement of a single guide RNA and high fidelity of gene editing. Here, we tested three Cas12a orthologs from human gut samples and identified a LtCas12a that utilizes...

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Detalles Bibliográficos
Autores principales: Chen, Ye, Meng, Lirong, Lang, Bin, Li, Lifang, Liu, Jiashuo, Wang, Yuyan, Huang, Zheying, Tian, Xun, Tian, Rui, Hu, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162949/
https://www.ncbi.nlm.nih.gov/pubmed/37159673
http://dx.doi.org/10.1016/j.crmeth.2023.100444

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