Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells

Programmed cell death protein 1 (PD-1), expressed on tumor-infiltrating T cells, is a T cell exhaustion marker. The mechanisms underlying PD-1 upregulation in CD4 T cells remain unknown. Here we develop nutrient-deprived media and a conditional knockout female mouse model to study the mechanism unde...

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Detalles Bibliográficos
Autores principales: Pandit, Mahesh, Kil, Yun-Seo, Ahn, Jae-Hee, Pokhrel, Ram Hari, Gu, Ye, Mishra, Sunil, Han, Youngjoo, Ouh, Yung-Taek, Kang, Ben, Jeong, Myeong Seon, Kim, Jong-Oh, Nam, Joo-Won, Ko, Hyun-Jeong, Chang, Jae-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162977/
https://www.ncbi.nlm.nih.gov/pubmed/37147330
http://dx.doi.org/10.1038/s41467-023-38316-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162977/
https://www.ncbi.nlm.nih.gov/pubmed/37147330
http://dx.doi.org/10.1038/s41467-023-38316-9

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