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Molecular determinants of inhibition of UCP1-mediated respiratory uncoupling

Brown adipose tissue expresses uncoupling protein 1 (UCP1), which dissipates energy as heat, making it a target for treating metabolic disorders. Here, we investigate how purine nucleotides inhibit respiration uncoupling by UCP1. Our molecular simulations predict that GDP and GTP bind UCP1 in the co...

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Detalles Bibliográficos
Autores principales:	Gagelin, Antoine, Largeau, Corentin, Masscheleyn, Sandrine, Piel, Mathilde S., Calderón-Mora, Daniel, Bouillaud, Frédéric, Hénin, Jérôme, Miroux, Bruno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162991/ https://www.ncbi.nlm.nih.gov/pubmed/37147287 http://dx.doi.org/10.1038/s41467-023-38219-9

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