Label-free characterization of organoids with quantitative confocal Raman spectral imaging

Stem cell-derived organoids have the potential to significantly improve the drug discovery process. However, a key challenge is monitoring the maturation process and drug response. In this issue of Cell Reports Methods, LaLone et al. have shown that quantitative confocal Raman spectral imaging, a la...

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Detalles Bibliográficos
Autores principales: Coughlan, Mark F., Perelman, Lev T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162994/
https://www.ncbi.nlm.nih.gov/pubmed/37159664
http://dx.doi.org/10.1016/j.crmeth.2023.100457
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author Coughlan, Mark F.
Perelman, Lev T.
author_facet Coughlan, Mark F.
Perelman, Lev T.
author_sort Coughlan, Mark F.
collection PubMed
description Stem cell-derived organoids have the potential to significantly improve the drug discovery process. However, a key challenge is monitoring the maturation process and drug response. In this issue of Cell Reports Methods, LaLone et al. have shown that quantitative confocal Raman spectral imaging, a label-free technique, can reliably monitor organoid development, drug accumulation, and drug metabolism.
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spelling pubmed-101629942023-05-07 Label-free characterization of organoids with quantitative confocal Raman spectral imaging Coughlan, Mark F. Perelman, Lev T. Cell Rep Methods Preview Stem cell-derived organoids have the potential to significantly improve the drug discovery process. However, a key challenge is monitoring the maturation process and drug response. In this issue of Cell Reports Methods, LaLone et al. have shown that quantitative confocal Raman spectral imaging, a label-free technique, can reliably monitor organoid development, drug accumulation, and drug metabolism. Elsevier 2023-04-13 /pmc/articles/PMC10162994/ /pubmed/37159664 http://dx.doi.org/10.1016/j.crmeth.2023.100457 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preview
Coughlan, Mark F.
Perelman, Lev T.
Label-free characterization of organoids with quantitative confocal Raman spectral imaging
title Label-free characterization of organoids with quantitative confocal Raman spectral imaging
title_full Label-free characterization of organoids with quantitative confocal Raman spectral imaging
title_fullStr Label-free characterization of organoids with quantitative confocal Raman spectral imaging
title_full_unstemmed Label-free characterization of organoids with quantitative confocal Raman spectral imaging
title_short Label-free characterization of organoids with quantitative confocal Raman spectral imaging
title_sort label-free characterization of organoids with quantitative confocal raman spectral imaging
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10162994/
https://www.ncbi.nlm.nih.gov/pubmed/37159664
http://dx.doi.org/10.1016/j.crmeth.2023.100457
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