In situ microwave fixation provides an instantaneous snapshot of the brain metabolome

Brain glucose metabolism is highly heterogeneous among brain regions and continues postmortem. In particular, we demonstrate exhaustion of glycogen and glucose and an increase in lactate production during conventional rapid brain resection and preservation by liquid nitrogen. In contrast, we show th...

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Detalles Bibliográficos
Autores principales: Juras, Jelena A., Webb, Madison B., Young, Lyndsay E.A., Markussen, Kia H., Hawkinson, Tara R., Buoncristiani, Michael D., Bolton, Kayli E., Coburn, Peyton T., Williams, Meredith I., Sun, Lisa P.Y., Sanders, William C., Bruntz, Ronald C., Conroy, Lindsey R., Wang, Chi, Gentry, Matthew S., Smith, Bret N., Sun, Ramon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163000/
https://www.ncbi.nlm.nih.gov/pubmed/37159672
http://dx.doi.org/10.1016/j.crmeth.2023.100455

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