Activity of pemetrexed in pre-clinical chordoma models and humans

Chordomas are rare slow growing tumors, arising from embryonic remnants of notochord with a close predilection for the axial skeleton. Recurrence is common and no effective standard medical therapy exists. Thymidylate synthase (TS), an intracellular enzyme, is a key rate-limiting enzyme of DNA biosy...

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Detalles Bibliográficos
Autores principales: Kesari, Santosh, Wang, Feng, Juarez, Tiffany, Ashili, Shashaanka, Patro, C. Pawan K., Carrillo, Jose, Nguyen, Minhdan, Truong, Judy, Levy, Joan, Sommer, Josh, Freed, Daniel M., Xiu, Joanne, Takasumi, Yuki, Bouffet, Eric, Gill, Jaya M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163028/
https://www.ncbi.nlm.nih.gov/pubmed/37147496
http://dx.doi.org/10.1038/s41598-023-34404-4

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