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Smoking as a risk factor for colorectal neoplasms in young individuals? A systematic meta-analysis

BACKGROUND AND AIMS: Early-onset colorectal neoplasms (EoCRN) include both benign and malign colorectal tumors, which occur before the age of 50. The incidence of EoCRN is rising worldwide. Tobacco smoking has previously been proven to be related to the development of various tumor types. However, i...

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Autores principales: Li, Qiang, Weitz, Jutta, Li, Chao, Schardey, Josefine, Weiss, Lena, Wirth, Ulrich, Zimmermann, Petra, Bazhin, Alexandr V., Werner, Jens, Kühn, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163071/
https://www.ncbi.nlm.nih.gov/pubmed/37147435
http://dx.doi.org/10.1007/s00384-023-04405-w
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author Li, Qiang
Weitz, Jutta
Li, Chao
Schardey, Josefine
Weiss, Lena
Wirth, Ulrich
Zimmermann, Petra
Bazhin, Alexandr V.
Werner, Jens
Kühn, Florian
author_facet Li, Qiang
Weitz, Jutta
Li, Chao
Schardey, Josefine
Weiss, Lena
Wirth, Ulrich
Zimmermann, Petra
Bazhin, Alexandr V.
Werner, Jens
Kühn, Florian
author_sort Li, Qiang
collection PubMed
description BACKGROUND AND AIMS: Early-onset colorectal neoplasms (EoCRN) include both benign and malign colorectal tumors, which occur before the age of 50. The incidence of EoCRN is rising worldwide. Tobacco smoking has previously been proven to be related to the development of various tumor types. However, its relationship with EoCRN is not clearly defined. Hence, we carried out a systematic review and a meta-analysis to evaluate the relationship between smoking status and the risk of EoCRN. METHODS: A systematic search of PubMed, EMBASE, and Web of Science up to September 7, 2022, was performed for studies that evaluated the association of smoking status with EoCRN. The quality of the case–control study was evaluated with the Newcastle‒Ottawa Scale. The quality of the cross-sectional studies was evaluated with the American Health Care Research and Quality checklist. Fixed-effects models were used to pool odds ratios (ORs) to evaluate the relationship between the risk of developing EoCRN and smoking status. The meta-analyses were performed with Review Manager version 5.4, and funnel plots and publication bias tests were produced by STATA software. RESULTS: A total of six studies were included in this meta-analysis. After pooling the results of these six studies, we found that current smokers carry a relatively high risk of developing EoCRN (OR, 1.33; 95% confidence interval [CI], 1.17–1.52) compared to never-smokers. Ex-smokers were not at a significantly increased risk for developing EoCRN (OR, 1.00; 95% CI, 0.86–1.18). DISCUSSION: Smoking behavior is significantly associated with an increased risk for developing EoCRN and might be one of the reasons for the increasing incidence. Ex-smokers who quit are not at significant risk of developing EoCRN. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00384-023-04405-w.
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spelling pubmed-101630712023-05-07 Smoking as a risk factor for colorectal neoplasms in young individuals? A systematic meta-analysis Li, Qiang Weitz, Jutta Li, Chao Schardey, Josefine Weiss, Lena Wirth, Ulrich Zimmermann, Petra Bazhin, Alexandr V. Werner, Jens Kühn, Florian Int J Colorectal Dis Review BACKGROUND AND AIMS: Early-onset colorectal neoplasms (EoCRN) include both benign and malign colorectal tumors, which occur before the age of 50. The incidence of EoCRN is rising worldwide. Tobacco smoking has previously been proven to be related to the development of various tumor types. However, its relationship with EoCRN is not clearly defined. Hence, we carried out a systematic review and a meta-analysis to evaluate the relationship between smoking status and the risk of EoCRN. METHODS: A systematic search of PubMed, EMBASE, and Web of Science up to September 7, 2022, was performed for studies that evaluated the association of smoking status with EoCRN. The quality of the case–control study was evaluated with the Newcastle‒Ottawa Scale. The quality of the cross-sectional studies was evaluated with the American Health Care Research and Quality checklist. Fixed-effects models were used to pool odds ratios (ORs) to evaluate the relationship between the risk of developing EoCRN and smoking status. The meta-analyses were performed with Review Manager version 5.4, and funnel plots and publication bias tests were produced by STATA software. RESULTS: A total of six studies were included in this meta-analysis. After pooling the results of these six studies, we found that current smokers carry a relatively high risk of developing EoCRN (OR, 1.33; 95% confidence interval [CI], 1.17–1.52) compared to never-smokers. Ex-smokers were not at a significantly increased risk for developing EoCRN (OR, 1.00; 95% CI, 0.86–1.18). DISCUSSION: Smoking behavior is significantly associated with an increased risk for developing EoCRN and might be one of the reasons for the increasing incidence. Ex-smokers who quit are not at significant risk of developing EoCRN. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00384-023-04405-w. Springer Berlin Heidelberg 2023-05-06 2023 /pmc/articles/PMC10163071/ /pubmed/37147435 http://dx.doi.org/10.1007/s00384-023-04405-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Li, Qiang
Weitz, Jutta
Li, Chao
Schardey, Josefine
Weiss, Lena
Wirth, Ulrich
Zimmermann, Petra
Bazhin, Alexandr V.
Werner, Jens
Kühn, Florian
Smoking as a risk factor for colorectal neoplasms in young individuals? A systematic meta-analysis
title Smoking as a risk factor for colorectal neoplasms in young individuals? A systematic meta-analysis
title_full Smoking as a risk factor for colorectal neoplasms in young individuals? A systematic meta-analysis
title_fullStr Smoking as a risk factor for colorectal neoplasms in young individuals? A systematic meta-analysis
title_full_unstemmed Smoking as a risk factor for colorectal neoplasms in young individuals? A systematic meta-analysis
title_short Smoking as a risk factor for colorectal neoplasms in young individuals? A systematic meta-analysis
title_sort smoking as a risk factor for colorectal neoplasms in young individuals? a systematic meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163071/
https://www.ncbi.nlm.nih.gov/pubmed/37147435
http://dx.doi.org/10.1007/s00384-023-04405-w
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