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Significant impact of time-of-day variation on metformin pharmacokinetics

AIMS/HYPOTHESIS: The objective was to investigate if metformin pharmacokinetics is modulated by time-of-day in humans using empirical and mechanistic pharmacokinetic modelling techniques on a large clinical dataset. This study also aimed to generate and test hypotheses on the underlying mechanisms,...

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Detalles Bibliográficos
Autores principales:	Türk, Denise, Scherer, Nina, Selzer, Dominik, Dings, Christiane, Hanke, Nina, Dallmann, Robert, Schwab, Matthias, Timmins, Peter, Nock, Valerie, Lehr, Thorsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163090/ https://www.ncbi.nlm.nih.gov/pubmed/36930251 http://dx.doi.org/10.1007/s00125-023-05898-4

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