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COMBINe enables automated detection and classification of neurons and astrocytes in tissue-cleared mouse brains

Tissue clearing renders entire organs transparent to accelerate whole-tissue imaging; for example, with light-sheet fluorescence microscopy. Yet, challenges remain in analyzing the large resulting 3D datasets that consist of terabytes of images and information on millions of labeled cells. Previous...

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Detalles Bibliográficos
Autores principales: Cai, Yuheng, Zhang, Xuying, Li, Chen, Ghashghaei, H. Troy, Greenbaum, Alon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163164/
https://www.ncbi.nlm.nih.gov/pubmed/37159668
http://dx.doi.org/10.1016/j.crmeth.2023.100454