Catch bond models may explain how force amplifies TCR signaling and antigen discrimination

The TCR integrates forces in its triggering process upon interaction with pMHC. Force elicits TCR catch-slip bonds with strong pMHCs but slip-only bonds with weak pMHCs. We develop two models and apply them to analyze 55 datasets, demonstrating the models’ ability to quantitatively integrate and cla...

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Detalles Bibliográficos
Autores principales: Choi, Hyun-Kyu, Cong, Peiwen, Ge, Chenghao, Natarajan, Aswin, Liu, Baoyu, Zhang, Yong, Li, Kaitao, Rushdi, Muaz Nik, Chen, Wei, Lou, Jizhong, Krogsgaard, Michelle, Zhu, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163261/
https://www.ncbi.nlm.nih.gov/pubmed/37147290
http://dx.doi.org/10.1038/s41467-023-38267-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163261/
https://www.ncbi.nlm.nih.gov/pubmed/37147290
http://dx.doi.org/10.1038/s41467-023-38267-1

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