Genetic dissection of triplicated chromosome 21 orthologs yields varying skeletal traits in Down syndrome model mice

Down syndrome (DS) phenotypes result from triplicated genes, but the effects of three copy genes are not well known. A mouse mapping panel genetically dissecting human chromosome 21 (Hsa21) syntenic regions was used to investigate the contributions and interactions of triplicated Hsa21 orthologous g...

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Detalles Bibliográficos
Autores principales: Sloan, Kourtney, Thomas, Jared, Blackwell, Matthew, Voisard, Deanna, Lana-Elola, Eva, Watson-Scales, Sheona, Roper, Daniel L., Wallace, Joseph M., Fisher, Elizabeth M. C., Tybulewicz, Victor L. J., Roper, Randall J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163323/
https://www.ncbi.nlm.nih.gov/pubmed/36939025
http://dx.doi.org/10.1242/dmm.049927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163323/
https://www.ncbi.nlm.nih.gov/pubmed/36939025
http://dx.doi.org/10.1242/dmm.049927

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