Neuronal overexpression of hTDP-43 in Caenorhabditis elegans impairs motor function

Transactive response DNA binding-protein 43 (TDP-43) is a conserved RNA/DNA-binding protein with a role in RNA metabolism and homeostasis. Aberrant TDP-43 functioning has been considered a major culprit in amyotrophic lateral sclerosis (ALS). Caenorhabditis elegans can be used to phenocopy ALS in vi...

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Detalles Bibliográficos
Autores principales: Koopman, Mandy, Güngördü, Lale, Seinstra, Renée I., Nollen, Ellen A.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163325/
https://www.ncbi.nlm.nih.gov/pubmed/37159576
http://dx.doi.org/10.17912/micropub.biology.000768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163325/
https://www.ncbi.nlm.nih.gov/pubmed/37159576
http://dx.doi.org/10.17912/micropub.biology.000768

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