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Clinicoradiological course of abemaciclib-induced pneumonitis with histology findings

A woman in her late 40s presented with multiple abnormal shadows on high-resolution CT (HRCT), was treated with abemaciclib for recurrent right breast cancer post-surgery and chemoradiation therapy. During the 10-month chemotherapy, HRCT revealed a recurrent pattern of a partly appearing and disappe...

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Autores principales: Okayasu, Kaori, Kawasaki, Tsutomu, Kumagai, Jiro, Miyazaki, Yasunari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163413/
https://www.ncbi.nlm.nih.gov/pubmed/37130630
http://dx.doi.org/10.1136/bcr-2022-254349
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author Okayasu, Kaori
Kawasaki, Tsutomu
Kumagai, Jiro
Miyazaki, Yasunari
author_facet Okayasu, Kaori
Kawasaki, Tsutomu
Kumagai, Jiro
Miyazaki, Yasunari
author_sort Okayasu, Kaori
collection PubMed
description A woman in her late 40s presented with multiple abnormal shadows on high-resolution CT (HRCT), was treated with abemaciclib for recurrent right breast cancer post-surgery and chemoradiation therapy. During the 10-month chemotherapy, HRCT revealed a recurrent pattern of a partly appearing and disappearing organising pneumonia pattern without clinical symptoms. Bronchoalveolar lavage analysis revealed lymphocytosis, while transbronchial lung biopsy revealed alveolitis with epithelial cell injury. Based on the diagnosis of drug-induced pneumonitis due to abemaciclib, the discontinuation of abemaciclib and administration of prednisolone were effective. Abnormal shadow on HRCT disappeared gradually, while elevated Krebs von den Lungen (KL)-6 and surfactant protein (SP)-D levels were restored to normal range. This is the first case report of abemaciclib-induced pneumonitis with histology findings. Since the severity of abemaciclib-induced pneumonitis ranges from mild to fatal, regular monitoring of pneumonitis with radiography, HRCT, and measurement of KL-6 and SP-D levels should be considered.
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spelling pubmed-101634132023-05-07 Clinicoradiological course of abemaciclib-induced pneumonitis with histology findings Okayasu, Kaori Kawasaki, Tsutomu Kumagai, Jiro Miyazaki, Yasunari BMJ Case Rep Case Reports: Adverse drug reactions and complications A woman in her late 40s presented with multiple abnormal shadows on high-resolution CT (HRCT), was treated with abemaciclib for recurrent right breast cancer post-surgery and chemoradiation therapy. During the 10-month chemotherapy, HRCT revealed a recurrent pattern of a partly appearing and disappearing organising pneumonia pattern without clinical symptoms. Bronchoalveolar lavage analysis revealed lymphocytosis, while transbronchial lung biopsy revealed alveolitis with epithelial cell injury. Based on the diagnosis of drug-induced pneumonitis due to abemaciclib, the discontinuation of abemaciclib and administration of prednisolone were effective. Abnormal shadow on HRCT disappeared gradually, while elevated Krebs von den Lungen (KL)-6 and surfactant protein (SP)-D levels were restored to normal range. This is the first case report of abemaciclib-induced pneumonitis with histology findings. Since the severity of abemaciclib-induced pneumonitis ranges from mild to fatal, regular monitoring of pneumonitis with radiography, HRCT, and measurement of KL-6 and SP-D levels should be considered. BMJ Publishing Group 2023-05-01 /pmc/articles/PMC10163413/ /pubmed/37130630 http://dx.doi.org/10.1136/bcr-2022-254349 Text en © BMJ Publishing Group Limited 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Case Reports: Adverse drug reactions and complications
Okayasu, Kaori
Kawasaki, Tsutomu
Kumagai, Jiro
Miyazaki, Yasunari
Clinicoradiological course of abemaciclib-induced pneumonitis with histology findings
title Clinicoradiological course of abemaciclib-induced pneumonitis with histology findings
title_full Clinicoradiological course of abemaciclib-induced pneumonitis with histology findings
title_fullStr Clinicoradiological course of abemaciclib-induced pneumonitis with histology findings
title_full_unstemmed Clinicoradiological course of abemaciclib-induced pneumonitis with histology findings
title_short Clinicoradiological course of abemaciclib-induced pneumonitis with histology findings
title_sort clinicoradiological course of abemaciclib-induced pneumonitis with histology findings
topic Case Reports: Adverse drug reactions and complications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163413/
https://www.ncbi.nlm.nih.gov/pubmed/37130630
http://dx.doi.org/10.1136/bcr-2022-254349
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