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Early markers of neurodevelopmental disorders based on general movements for very preterm infants: study protocol for a multicentre prospective cohort study in a clinical setting in China

INTRODUCTION: Very preterm (VPT) infants may experience varying degrees of neurodevelopmental challenges. Lack of early markers for neurodevelopmental disorders may delay referral to early interventions. The detailed General Movements Assessment (GMA) could help us to identify early markers for VPT...

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Autores principales: Wang, Jun, Shen, Xiushu, Yang, Hong, Li, Zhihua, Liang, Shuyi, Wu, Furong, Tang, Xinglu, Mao, Xujie, He, Minsi, Xu, Fengdan, Li, Xueyan, Li, Chengmei, Qian, Shuangshuang, Zhu, Xiaoyun, Meng, Fanzhe, Wu, Yun, Gao, Herong, Cao, Jiayan, Yin, Huanhuan, Wang, Yin, Huang, Yanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163464/
https://www.ncbi.nlm.nih.gov/pubmed/37142311
http://dx.doi.org/10.1136/bmjopen-2022-069692
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author Wang, Jun
Shen, Xiushu
Yang, Hong
Li, Zhihua
Liang, Shuyi
Wu, Furong
Tang, Xinglu
Mao, Xujie
He, Minsi
Xu, Fengdan
Li, Xueyan
Li, Chengmei
Qian, Shuangshuang
Zhu, Xiaoyun
Meng, Fanzhe
Wu, Yun
Gao, Herong
Cao, Jiayan
Yin, Huanhuan
Wang, Yin
Huang, Yanxiang
author_facet Wang, Jun
Shen, Xiushu
Yang, Hong
Li, Zhihua
Liang, Shuyi
Wu, Furong
Tang, Xinglu
Mao, Xujie
He, Minsi
Xu, Fengdan
Li, Xueyan
Li, Chengmei
Qian, Shuangshuang
Zhu, Xiaoyun
Meng, Fanzhe
Wu, Yun
Gao, Herong
Cao, Jiayan
Yin, Huanhuan
Wang, Yin
Huang, Yanxiang
author_sort Wang, Jun
collection PubMed
description INTRODUCTION: Very preterm (VPT) infants may experience varying degrees of neurodevelopmental challenges. Lack of early markers for neurodevelopmental disorders may delay referral to early interventions. The detailed General Movements Assessment (GMA) could help us to identify early markers for VPT infants at risk of atypical neurodevelopmental clinical phenotype in the very early stage of life as soon as possible. Preterm infants with high risk of atypical neurodevelopmental outcomes will have the best possible start to life if early precise intervention in critical developmental windows is allowed. METHODS AND ANALYSIS: This is a nationwide, multicentric prospective cohort study that will recruit 577 infants born <32 weeks of age. This study will determine the diagnostic value of the developmental trajectory of general movements (GMs) at writhing and fidgety age with qualitative assessment for different atypical developmental outcomes at 2 years evaluated by the Griffiths Development Scales-Chinese. The difference in the General Movement Optimality Score (GMOS) will be used to distinguish normal (N), poor repertoire (PR) and cramped sychronised (CS) GMs. We plan to build the percentile rank of GMOS (median, 10th, 25th, 75th and 90th percentile rank) in N, PR and CS of each global GM category and analyse the relationship between GMOS in writhing movements and Motor Optimality Score (MOS) in fidgety movements based on the detailed GMA. We explore the subcategories of the GMOS list, and MOS list that may identify specific early markers that help us to identify and predict different clinical phenotypes and functional outcomes in VPT infants. ETHICS AND DISSEMINATION: The central ethical approval has been confirmed from the Research Ethical Board of Children’s Hospital of Fudan University (ref approval no. 2022(029)) and the local ethical approval has been also obtained by the corresponding ethics committees of the recruitment sites. Critical analysis of the study results will contribute to providing a basis for hierarchical management and precise intervention for preterm infants in very early life. TRIAL REGISTRATION NUMBER: ChiCTR2200064521.
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spelling pubmed-101634642023-05-07 Early markers of neurodevelopmental disorders based on general movements for very preterm infants: study protocol for a multicentre prospective cohort study in a clinical setting in China Wang, Jun Shen, Xiushu Yang, Hong Li, Zhihua Liang, Shuyi Wu, Furong Tang, Xinglu Mao, Xujie He, Minsi Xu, Fengdan Li, Xueyan Li, Chengmei Qian, Shuangshuang Zhu, Xiaoyun Meng, Fanzhe Wu, Yun Gao, Herong Cao, Jiayan Yin, Huanhuan Wang, Yin Huang, Yanxiang BMJ Open Paediatrics INTRODUCTION: Very preterm (VPT) infants may experience varying degrees of neurodevelopmental challenges. Lack of early markers for neurodevelopmental disorders may delay referral to early interventions. The detailed General Movements Assessment (GMA) could help us to identify early markers for VPT infants at risk of atypical neurodevelopmental clinical phenotype in the very early stage of life as soon as possible. Preterm infants with high risk of atypical neurodevelopmental outcomes will have the best possible start to life if early precise intervention in critical developmental windows is allowed. METHODS AND ANALYSIS: This is a nationwide, multicentric prospective cohort study that will recruit 577 infants born <32 weeks of age. This study will determine the diagnostic value of the developmental trajectory of general movements (GMs) at writhing and fidgety age with qualitative assessment for different atypical developmental outcomes at 2 years evaluated by the Griffiths Development Scales-Chinese. The difference in the General Movement Optimality Score (GMOS) will be used to distinguish normal (N), poor repertoire (PR) and cramped sychronised (CS) GMs. We plan to build the percentile rank of GMOS (median, 10th, 25th, 75th and 90th percentile rank) in N, PR and CS of each global GM category and analyse the relationship between GMOS in writhing movements and Motor Optimality Score (MOS) in fidgety movements based on the detailed GMA. We explore the subcategories of the GMOS list, and MOS list that may identify specific early markers that help us to identify and predict different clinical phenotypes and functional outcomes in VPT infants. ETHICS AND DISSEMINATION: The central ethical approval has been confirmed from the Research Ethical Board of Children’s Hospital of Fudan University (ref approval no. 2022(029)) and the local ethical approval has been also obtained by the corresponding ethics committees of the recruitment sites. Critical analysis of the study results will contribute to providing a basis for hierarchical management and precise intervention for preterm infants in very early life. TRIAL REGISTRATION NUMBER: ChiCTR2200064521. BMJ Publishing Group 2023-05-04 /pmc/articles/PMC10163464/ /pubmed/37142311 http://dx.doi.org/10.1136/bmjopen-2022-069692 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Paediatrics
Wang, Jun
Shen, Xiushu
Yang, Hong
Li, Zhihua
Liang, Shuyi
Wu, Furong
Tang, Xinglu
Mao, Xujie
He, Minsi
Xu, Fengdan
Li, Xueyan
Li, Chengmei
Qian, Shuangshuang
Zhu, Xiaoyun
Meng, Fanzhe
Wu, Yun
Gao, Herong
Cao, Jiayan
Yin, Huanhuan
Wang, Yin
Huang, Yanxiang
Early markers of neurodevelopmental disorders based on general movements for very preterm infants: study protocol for a multicentre prospective cohort study in a clinical setting in China
title Early markers of neurodevelopmental disorders based on general movements for very preterm infants: study protocol for a multicentre prospective cohort study in a clinical setting in China
title_full Early markers of neurodevelopmental disorders based on general movements for very preterm infants: study protocol for a multicentre prospective cohort study in a clinical setting in China
title_fullStr Early markers of neurodevelopmental disorders based on general movements for very preterm infants: study protocol for a multicentre prospective cohort study in a clinical setting in China
title_full_unstemmed Early markers of neurodevelopmental disorders based on general movements for very preterm infants: study protocol for a multicentre prospective cohort study in a clinical setting in China
title_short Early markers of neurodevelopmental disorders based on general movements for very preterm infants: study protocol for a multicentre prospective cohort study in a clinical setting in China
title_sort early markers of neurodevelopmental disorders based on general movements for very preterm infants: study protocol for a multicentre prospective cohort study in a clinical setting in china
topic Paediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163464/
https://www.ncbi.nlm.nih.gov/pubmed/37142311
http://dx.doi.org/10.1136/bmjopen-2022-069692
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