Effect of hepatic NPC1L1 on cholesterol gallstone disease and its mechanism

Cholesterol gallstone disease (CGD) is associated with bile cholesterol supersaturation. The Niemann-Pick C1-like 1 (NPC1L1), the inhibitory target of ezetimibe (EZE), is a critical sterol transporter of cholesterol absorption. Intestinal NPC1L1 facilitates the absorption of cholesterol, whereas hep...

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Detalles Bibliográficos
Autores principales: Mo, Pingfan, Chen, Hongtan, Jiang, Xin, Hu, Fengling, Zhang, Fenming, Shan, Guodong, Chen, Wenguo, Li, Sha, Xu, Guoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163659/
https://www.ncbi.nlm.nih.gov/pubmed/37159680
http://dx.doi.org/10.1016/j.heliyon.2023.e15757

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