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Knowledge mapping of nano drug delivery systems across blood - Brain barrier from 1996 to 2022: A bibliometric analysis

BACKGROUND: The blood-brain barrier (BBB) is a natural physiological barrier that protects the central nervous system from foreign substances and limits the delivery of drugs to the brain. Nanotechnology has opened up new possibilities for drug delivery in the brain. Over several decades, various Na...

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Detalles Bibliográficos
Autores principales: Zhong, Dayuan, Gan, Zhenyu, Zheng, Mengxue, Li, Lan, Cheng, Hui, Luo, Hongsheng, Liu, Deliang, Liu, Pingwen, Li, Huanjie, Ou, Xueming, Deng, Yihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163661/
https://www.ncbi.nlm.nih.gov/pubmed/37159702
http://dx.doi.org/10.1016/j.heliyon.2023.e15828
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author Zhong, Dayuan
Gan, Zhenyu
Zheng, Mengxue
Li, Lan
Cheng, Hui
Luo, Hongsheng
Liu, Deliang
Liu, Pingwen
Li, Huanjie
Ou, Xueming
Deng, Yihui
author_facet Zhong, Dayuan
Gan, Zhenyu
Zheng, Mengxue
Li, Lan
Cheng, Hui
Luo, Hongsheng
Liu, Deliang
Liu, Pingwen
Li, Huanjie
Ou, Xueming
Deng, Yihui
author_sort Zhong, Dayuan
collection PubMed
description BACKGROUND: The blood-brain barrier (BBB) is a natural physiological barrier that protects the central nervous system from foreign substances and limits the delivery of drugs to the brain. Nanotechnology has opened up new possibilities for drug delivery in the brain. Over several decades, various Nanoparticle Drug Delivery Systems (NDDS) that can cross the BBB have been developed for targeted delivery in the brain. To gain a comprehensive understanding of the current research hotspots and trends of NDDS across the BBB, this paper employs bibliometric analysis of articles published in the core database of Web of Science (WOS) from 1996 to 2022. METHOD: A search for relevant research literature on NDDS that can cross the BBB was conducted in the Web of Science database, covering the period from 1996 to 2022. The Bibliometrix R-4.0 software package was used to analyze data related to the countries of publication, research institutions, journals, citations, and keywords. The analysis aimed to identify the co-occurrence of keywords in the documents, including their titles and abstracts. Additionally, cooperative network analyses of authors, institutions, and countries of publication were conducted. RESULTS: A total of 436 articles were analyzed, originating from 174 journals and 13 books, with the majority published in Q1 and Q2 journals. Contributors from 53 countries or regions participated in the publication of these articles, with China, the United States, and India having the highest number of articles by correspondent authors, and China, the United States, and Germany being the most cited countries. Fudan University, Hacettepe University, and Sichuan University were the top three institutions with the most publications. Among the 436 articles analyzed, 1337 keywords and 1450 keywords plus were identified. Factor analysis grouped the keywords plus into two categories: drug delivery systems, polymeric nanoparticles, gold nanoparticles, transferrin, and others, and drug, delivery, efficiency, expression, and mechanism. CONCLUSION: The research on NDDS that can cross the BBB is gradually receiving attention, and the recognition and cooperation in this field have increased.
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spelling pubmed-101636612023-05-07 Knowledge mapping of nano drug delivery systems across blood - Brain barrier from 1996 to 2022: A bibliometric analysis Zhong, Dayuan Gan, Zhenyu Zheng, Mengxue Li, Lan Cheng, Hui Luo, Hongsheng Liu, Deliang Liu, Pingwen Li, Huanjie Ou, Xueming Deng, Yihui Heliyon Review Article BACKGROUND: The blood-brain barrier (BBB) is a natural physiological barrier that protects the central nervous system from foreign substances and limits the delivery of drugs to the brain. Nanotechnology has opened up new possibilities for drug delivery in the brain. Over several decades, various Nanoparticle Drug Delivery Systems (NDDS) that can cross the BBB have been developed for targeted delivery in the brain. To gain a comprehensive understanding of the current research hotspots and trends of NDDS across the BBB, this paper employs bibliometric analysis of articles published in the core database of Web of Science (WOS) from 1996 to 2022. METHOD: A search for relevant research literature on NDDS that can cross the BBB was conducted in the Web of Science database, covering the period from 1996 to 2022. The Bibliometrix R-4.0 software package was used to analyze data related to the countries of publication, research institutions, journals, citations, and keywords. The analysis aimed to identify the co-occurrence of keywords in the documents, including their titles and abstracts. Additionally, cooperative network analyses of authors, institutions, and countries of publication were conducted. RESULTS: A total of 436 articles were analyzed, originating from 174 journals and 13 books, with the majority published in Q1 and Q2 journals. Contributors from 53 countries or regions participated in the publication of these articles, with China, the United States, and India having the highest number of articles by correspondent authors, and China, the United States, and Germany being the most cited countries. Fudan University, Hacettepe University, and Sichuan University were the top three institutions with the most publications. Among the 436 articles analyzed, 1337 keywords and 1450 keywords plus were identified. Factor analysis grouped the keywords plus into two categories: drug delivery systems, polymeric nanoparticles, gold nanoparticles, transferrin, and others, and drug, delivery, efficiency, expression, and mechanism. CONCLUSION: The research on NDDS that can cross the BBB is gradually receiving attention, and the recognition and cooperation in this field have increased. Elsevier 2023-04-26 /pmc/articles/PMC10163661/ /pubmed/37159702 http://dx.doi.org/10.1016/j.heliyon.2023.e15828 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Zhong, Dayuan
Gan, Zhenyu
Zheng, Mengxue
Li, Lan
Cheng, Hui
Luo, Hongsheng
Liu, Deliang
Liu, Pingwen
Li, Huanjie
Ou, Xueming
Deng, Yihui
Knowledge mapping of nano drug delivery systems across blood - Brain barrier from 1996 to 2022: A bibliometric analysis
title Knowledge mapping of nano drug delivery systems across blood - Brain barrier from 1996 to 2022: A bibliometric analysis
title_full Knowledge mapping of nano drug delivery systems across blood - Brain barrier from 1996 to 2022: A bibliometric analysis
title_fullStr Knowledge mapping of nano drug delivery systems across blood - Brain barrier from 1996 to 2022: A bibliometric analysis
title_full_unstemmed Knowledge mapping of nano drug delivery systems across blood - Brain barrier from 1996 to 2022: A bibliometric analysis
title_short Knowledge mapping of nano drug delivery systems across blood - Brain barrier from 1996 to 2022: A bibliometric analysis
title_sort knowledge mapping of nano drug delivery systems across blood - brain barrier from 1996 to 2022: a bibliometric analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163661/
https://www.ncbi.nlm.nih.gov/pubmed/37159702
http://dx.doi.org/10.1016/j.heliyon.2023.e15828
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