The oncogenic role of NF1 in gallbladder cancer through regulation of YAP1 stability by direct interaction with YAP1

BACKGROUND: Gallbladder cancer (GBC) is the most prevalent and invasive biliary tract malignancy. As a GTPase-activating protein, Neurofibromin 1 (NF1) is a tumor suppressor that negatively regulates the RAS signaling pathway, and its abnormality leads to neurofibromatosis type 1 (NF-1) disease. How...

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Detalles Bibliográficos
Autores principales: Zhang, Lingxiao, Jiang, Lin, Zeng, Ling, Jin, Zhaohui, Dong, Xuanjia, Zhang, Yuhan, Chen, Litian, Shu, Yijun, Liu, Yingbin, Huang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163693/
https://www.ncbi.nlm.nih.gov/pubmed/37147639
http://dx.doi.org/10.1186/s12967-023-04157-9

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