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Modelling count, bounded and skewed continuous outcomes in physical activity research: beyond linear regression models

BACKGROUND: Inference using standard linear regression models (LMs) relies on assumptions that are rarely satisfied in practice. Substantial departures, if not addressed, have serious impacts on any inference and conclusions; potentially rendering them invalid and misleading. Count, bounded and skew...

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Autores principales: Akram, Muhammad, Cerin, Ester, Lamb, Karen E., White, Simon R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163772/
https://www.ncbi.nlm.nih.gov/pubmed/37147664
http://dx.doi.org/10.1186/s12966-023-01460-y
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author Akram, Muhammad
Cerin, Ester
Lamb, Karen E.
White, Simon R.
author_facet Akram, Muhammad
Cerin, Ester
Lamb, Karen E.
White, Simon R.
author_sort Akram, Muhammad
collection PubMed
description BACKGROUND: Inference using standard linear regression models (LMs) relies on assumptions that are rarely satisfied in practice. Substantial departures, if not addressed, have serious impacts on any inference and conclusions; potentially rendering them invalid and misleading. Count, bounded and skewed outcomes, common in physical activity research, can substantially violate LM assumptions. A common approach to handle these is to transform the outcome and apply a LM. However, a transformation may not suffice. METHODS: In this paper, we introduce the generalized linear model (GLM), a generalization of the LM, as an approach for the appropriate modelling of count and non-normally distributed (i.e., bounded and skewed) outcomes. Using data from a study of physical activity among older adults, we demonstrate appropriate methods to analyse count, bounded and skewed outcomes. RESULTS: We show how fitting an LM when inappropriate, especially for the type of outcomes commonly encountered in physical activity research, substantially impacts the analysis, inference, and conclusions compared to a GLM. CONCLUSIONS: GLMs which more appropriately model non-normally distributed response variables should be considered as more suitable approaches for managing count, bounded and skewed outcomes rather than simply relying on transformations. We recommend that physical activity researchers add the GLM to their statistical toolboxes and become aware of situations when GLMs are a better method than traditional approaches for modeling count, bounded and skewed outcomes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12966-023-01460-y.
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spelling pubmed-101637722023-05-07 Modelling count, bounded and skewed continuous outcomes in physical activity research: beyond linear regression models Akram, Muhammad Cerin, Ester Lamb, Karen E. White, Simon R. Int J Behav Nutr Phys Act Methodology BACKGROUND: Inference using standard linear regression models (LMs) relies on assumptions that are rarely satisfied in practice. Substantial departures, if not addressed, have serious impacts on any inference and conclusions; potentially rendering them invalid and misleading. Count, bounded and skewed outcomes, common in physical activity research, can substantially violate LM assumptions. A common approach to handle these is to transform the outcome and apply a LM. However, a transformation may not suffice. METHODS: In this paper, we introduce the generalized linear model (GLM), a generalization of the LM, as an approach for the appropriate modelling of count and non-normally distributed (i.e., bounded and skewed) outcomes. Using data from a study of physical activity among older adults, we demonstrate appropriate methods to analyse count, bounded and skewed outcomes. RESULTS: We show how fitting an LM when inappropriate, especially for the type of outcomes commonly encountered in physical activity research, substantially impacts the analysis, inference, and conclusions compared to a GLM. CONCLUSIONS: GLMs which more appropriately model non-normally distributed response variables should be considered as more suitable approaches for managing count, bounded and skewed outcomes rather than simply relying on transformations. We recommend that physical activity researchers add the GLM to their statistical toolboxes and become aware of situations when GLMs are a better method than traditional approaches for modeling count, bounded and skewed outcomes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12966-023-01460-y. BioMed Central 2023-05-05 /pmc/articles/PMC10163772/ /pubmed/37147664 http://dx.doi.org/10.1186/s12966-023-01460-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Methodology
Akram, Muhammad
Cerin, Ester
Lamb, Karen E.
White, Simon R.
Modelling count, bounded and skewed continuous outcomes in physical activity research: beyond linear regression models
title Modelling count, bounded and skewed continuous outcomes in physical activity research: beyond linear regression models
title_full Modelling count, bounded and skewed continuous outcomes in physical activity research: beyond linear regression models
title_fullStr Modelling count, bounded and skewed continuous outcomes in physical activity research: beyond linear regression models
title_full_unstemmed Modelling count, bounded and skewed continuous outcomes in physical activity research: beyond linear regression models
title_short Modelling count, bounded and skewed continuous outcomes in physical activity research: beyond linear regression models
title_sort modelling count, bounded and skewed continuous outcomes in physical activity research: beyond linear regression models
topic Methodology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163772/
https://www.ncbi.nlm.nih.gov/pubmed/37147664
http://dx.doi.org/10.1186/s12966-023-01460-y
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