Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis

Tuberculosis (TB) diagnosis still remains to be a challenge with the currently used immune based diagnostic methods particularly Interferon Gamma Release Assay due to the sensitivity issues and their inability in differentiating stages of TB infection. Immune markers are valuable sources for underst...

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Autores principales: Sampath, Pavithra, Rajamanickam, Anuradha, Thiruvengadam, Kannan, Natarajan, Alangudi Palaniappan, Hissar, Syed, Dhanapal, Madhavan, Thangavelu, Bharathiraja, Jayabal, Lavanya, Ramesh, Paranchi Murugesan, Ranganathan, Uma Devi, Babu, Subash, Bethunaickan, Ramalingam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163852/
https://www.ncbi.nlm.nih.gov/pubmed/37149713
http://dx.doi.org/10.1038/s41598-023-34530-z
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author Sampath, Pavithra
Rajamanickam, Anuradha
Thiruvengadam, Kannan
Natarajan, Alangudi Palaniappan
Hissar, Syed
Dhanapal, Madhavan
Thangavelu, Bharathiraja
Jayabal, Lavanya
Ramesh, Paranchi Murugesan
Ranganathan, Uma Devi
Babu, Subash
Bethunaickan, Ramalingam
author_facet Sampath, Pavithra
Rajamanickam, Anuradha
Thiruvengadam, Kannan
Natarajan, Alangudi Palaniappan
Hissar, Syed
Dhanapal, Madhavan
Thangavelu, Bharathiraja
Jayabal, Lavanya
Ramesh, Paranchi Murugesan
Ranganathan, Uma Devi
Babu, Subash
Bethunaickan, Ramalingam
author_sort Sampath, Pavithra
collection PubMed
description Tuberculosis (TB) diagnosis still remains to be a challenge with the currently used immune based diagnostic methods particularly Interferon Gamma Release Assay due to the sensitivity issues and their inability in differentiating stages of TB infection. Immune markers are valuable sources for understanding disease biology and are easily accessible. Chemokines, the stimulant, and the shaper of host immune responses are the vital hub for disease mediated dysregulation and their varied levels in TB disease are considered as an important marker to define the disease status. Hence, we wanted to examine the levels of chemokines among the individuals with drug-resistant, drug-sensitive, and latent TB compared to healthy individuals. Our results demonstrated that the differential levels of chemokines between the study groups and revealed that CXCL10 and CXCL9 as potential markers of drug-resistant and drug-sensitive TB with better stage discriminating abilities.
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spelling pubmed-101638522023-05-08 Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis Sampath, Pavithra Rajamanickam, Anuradha Thiruvengadam, Kannan Natarajan, Alangudi Palaniappan Hissar, Syed Dhanapal, Madhavan Thangavelu, Bharathiraja Jayabal, Lavanya Ramesh, Paranchi Murugesan Ranganathan, Uma Devi Babu, Subash Bethunaickan, Ramalingam Sci Rep Article Tuberculosis (TB) diagnosis still remains to be a challenge with the currently used immune based diagnostic methods particularly Interferon Gamma Release Assay due to the sensitivity issues and their inability in differentiating stages of TB infection. Immune markers are valuable sources for understanding disease biology and are easily accessible. Chemokines, the stimulant, and the shaper of host immune responses are the vital hub for disease mediated dysregulation and their varied levels in TB disease are considered as an important marker to define the disease status. Hence, we wanted to examine the levels of chemokines among the individuals with drug-resistant, drug-sensitive, and latent TB compared to healthy individuals. Our results demonstrated that the differential levels of chemokines between the study groups and revealed that CXCL10 and CXCL9 as potential markers of drug-resistant and drug-sensitive TB with better stage discriminating abilities. Nature Publishing Group UK 2023-05-06 /pmc/articles/PMC10163852/ /pubmed/37149713 http://dx.doi.org/10.1038/s41598-023-34530-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Sampath, Pavithra
Rajamanickam, Anuradha
Thiruvengadam, Kannan
Natarajan, Alangudi Palaniappan
Hissar, Syed
Dhanapal, Madhavan
Thangavelu, Bharathiraja
Jayabal, Lavanya
Ramesh, Paranchi Murugesan
Ranganathan, Uma Devi
Babu, Subash
Bethunaickan, Ramalingam
Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis
title Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis
title_full Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis
title_fullStr Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis
title_full_unstemmed Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis
title_short Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis
title_sort plasma chemokines cxcl10 and cxcl9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163852/
https://www.ncbi.nlm.nih.gov/pubmed/37149713
http://dx.doi.org/10.1038/s41598-023-34530-z
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