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Biochemical characterization of actin assembly mechanisms with ALS-associated profilin variants
Eight separate mutations in the actin-binding protein profilin-1 have been identified as a rare cause of amyotrophic lateral sclerosis (ALS). Profilin is essential for many neuronal cell processes through its regulation of lipids, nuclear signals, and cytoskeletal dynamics, including actin filament...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163920/ https://www.ncbi.nlm.nih.gov/pubmed/35248815 http://dx.doi.org/10.1016/j.ejcb.2022.151212 |