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Association between hypersomnolence and the COVID-19 pandemic: The International COVID-19 Sleep Study (ICOSS)

BACKGROUND: The COVID-19 pandemic and related restriction measures have affected our daily life, sleep, and circadian rhythms worldwide. Their effects on hypersomnolence and fatigue remain unclear. METHODS: The International COVID-19 Sleep Study questionnaire which included items on hypersomnolence...

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Autores principales: Sarkanen, Tomi, Partinen, Markku, Bjorvatn, Bjørn, Merikanto, Ilona, Benedict, Christian, Nadorff, Michael R., Bolstad, Courtney J., Espie, Colin, Matsui, Kentaro, Chung, Frances, Morin, Charles M., Wing, Yun Kwok, Penzel, Thomas, Macêdo, Tainá, Mota-Rolim, Sérgio, Holzinger, Brigitte, Plazzi, Giuseppe, De Gennaro, Luigi, Landtblom, Anne-Marie, Inoue, Yuichi, Sieminski, Mariuz, Leger, Damien, Dauvilliers, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163923/
https://www.ncbi.nlm.nih.gov/pubmed/37156053
http://dx.doi.org/10.1016/j.sleep.2023.04.024
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author Sarkanen, Tomi
Partinen, Markku
Bjorvatn, Bjørn
Merikanto, Ilona
Benedict, Christian
Nadorff, Michael R.
Bolstad, Courtney J.
Espie, Colin
Matsui, Kentaro
Chung, Frances
Morin, Charles M.
Wing, Yun Kwok
Penzel, Thomas
Macêdo, Tainá
Mota-Rolim, Sérgio
Holzinger, Brigitte
Plazzi, Giuseppe
De Gennaro, Luigi
Landtblom, Anne-Marie
Inoue, Yuichi
Sieminski, Mariuz
Leger, Damien
Dauvilliers, Yves
author_facet Sarkanen, Tomi
Partinen, Markku
Bjorvatn, Bjørn
Merikanto, Ilona
Benedict, Christian
Nadorff, Michael R.
Bolstad, Courtney J.
Espie, Colin
Matsui, Kentaro
Chung, Frances
Morin, Charles M.
Wing, Yun Kwok
Penzel, Thomas
Macêdo, Tainá
Mota-Rolim, Sérgio
Holzinger, Brigitte
Plazzi, Giuseppe
De Gennaro, Luigi
Landtblom, Anne-Marie
Inoue, Yuichi
Sieminski, Mariuz
Leger, Damien
Dauvilliers, Yves
author_sort Sarkanen, Tomi
collection PubMed
description BACKGROUND: The COVID-19 pandemic and related restriction measures have affected our daily life, sleep, and circadian rhythms worldwide. Their effects on hypersomnolence and fatigue remain unclear. METHODS: The International COVID-19 Sleep Study questionnaire which included items on hypersomnolence such as excessive daytime sleepiness (EDS), and excessive quantity of sleep (EQS), as well as sociodemographic factors, sleep patterns, psychological symptoms, and quality of life was distributed in 15 countries across the world from May to September in 2020. RESULTS: Altogether responses from 18,785 survey participants (65% women, median age 39 years) were available for analysis. Only 2.8% reported having had COVID-19. Compared to before the pandemic, the prevalence of EDS, EQS, and fatigue increased from 17.9% to 25.5%, 1.6%–4.9%, and 19.4%–28.3% amid the pandemic, respectively. In univariate logistic regression models, reports of having a COVID-19 were associated with EQS (OR 5.3; 95%-CI 3.6–8.0), EDS (2.6; 2.0–3.4), and fatigue (2.8; 2.1–3.6). In adjusted multivariate logistic regression, sleep duration shorter than desired (3.9; 3.2–4.7), depressive symptoms (3.1; 2.7–3.5), use of hypnotics (2.3; 1.9–2.8), and having reported COVID-19 (1.9; 1.3–2.6) remained strong predictors of EDS. Similar associations emerged for fatigue. In the multivariate model, depressive symptoms (4.1; 3.6–4.6) and reports of having COVID-19 (2.0; 1.4–2.8) remained associated with EQS. CONCLUSIONS: A large increase in EDS, EQS, and fatigue occurred due to the COVID-19 pandemic, and especially in self-reported cases of COVID-19. These findings warrant a thorough understanding of their pathophysiology to target prevention and treatment strategies for long COVID condition.
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spelling pubmed-101639232023-05-08 Association between hypersomnolence and the COVID-19 pandemic: The International COVID-19 Sleep Study (ICOSS) Sarkanen, Tomi Partinen, Markku Bjorvatn, Bjørn Merikanto, Ilona Benedict, Christian Nadorff, Michael R. Bolstad, Courtney J. Espie, Colin Matsui, Kentaro Chung, Frances Morin, Charles M. Wing, Yun Kwok Penzel, Thomas Macêdo, Tainá Mota-Rolim, Sérgio Holzinger, Brigitte Plazzi, Giuseppe De Gennaro, Luigi Landtblom, Anne-Marie Inoue, Yuichi Sieminski, Mariuz Leger, Damien Dauvilliers, Yves Sleep Med Article BACKGROUND: The COVID-19 pandemic and related restriction measures have affected our daily life, sleep, and circadian rhythms worldwide. Their effects on hypersomnolence and fatigue remain unclear. METHODS: The International COVID-19 Sleep Study questionnaire which included items on hypersomnolence such as excessive daytime sleepiness (EDS), and excessive quantity of sleep (EQS), as well as sociodemographic factors, sleep patterns, psychological symptoms, and quality of life was distributed in 15 countries across the world from May to September in 2020. RESULTS: Altogether responses from 18,785 survey participants (65% women, median age 39 years) were available for analysis. Only 2.8% reported having had COVID-19. Compared to before the pandemic, the prevalence of EDS, EQS, and fatigue increased from 17.9% to 25.5%, 1.6%–4.9%, and 19.4%–28.3% amid the pandemic, respectively. In univariate logistic regression models, reports of having a COVID-19 were associated with EQS (OR 5.3; 95%-CI 3.6–8.0), EDS (2.6; 2.0–3.4), and fatigue (2.8; 2.1–3.6). In adjusted multivariate logistic regression, sleep duration shorter than desired (3.9; 3.2–4.7), depressive symptoms (3.1; 2.7–3.5), use of hypnotics (2.3; 1.9–2.8), and having reported COVID-19 (1.9; 1.3–2.6) remained strong predictors of EDS. Similar associations emerged for fatigue. In the multivariate model, depressive symptoms (4.1; 3.6–4.6) and reports of having COVID-19 (2.0; 1.4–2.8) remained associated with EQS. CONCLUSIONS: A large increase in EDS, EQS, and fatigue occurred due to the COVID-19 pandemic, and especially in self-reported cases of COVID-19. These findings warrant a thorough understanding of their pathophysiology to target prevention and treatment strategies for long COVID condition. The Author(s). Published by Elsevier B.V. 2023-07 2023-05-06 /pmc/articles/PMC10163923/ /pubmed/37156053 http://dx.doi.org/10.1016/j.sleep.2023.04.024 Text en © 2023 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Sarkanen, Tomi
Partinen, Markku
Bjorvatn, Bjørn
Merikanto, Ilona
Benedict, Christian
Nadorff, Michael R.
Bolstad, Courtney J.
Espie, Colin
Matsui, Kentaro
Chung, Frances
Morin, Charles M.
Wing, Yun Kwok
Penzel, Thomas
Macêdo, Tainá
Mota-Rolim, Sérgio
Holzinger, Brigitte
Plazzi, Giuseppe
De Gennaro, Luigi
Landtblom, Anne-Marie
Inoue, Yuichi
Sieminski, Mariuz
Leger, Damien
Dauvilliers, Yves
Association between hypersomnolence and the COVID-19 pandemic: The International COVID-19 Sleep Study (ICOSS)
title Association between hypersomnolence and the COVID-19 pandemic: The International COVID-19 Sleep Study (ICOSS)
title_full Association between hypersomnolence and the COVID-19 pandemic: The International COVID-19 Sleep Study (ICOSS)
title_fullStr Association between hypersomnolence and the COVID-19 pandemic: The International COVID-19 Sleep Study (ICOSS)
title_full_unstemmed Association between hypersomnolence and the COVID-19 pandemic: The International COVID-19 Sleep Study (ICOSS)
title_short Association between hypersomnolence and the COVID-19 pandemic: The International COVID-19 Sleep Study (ICOSS)
title_sort association between hypersomnolence and the covid-19 pandemic: the international covid-19 sleep study (icoss)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163923/
https://www.ncbi.nlm.nih.gov/pubmed/37156053
http://dx.doi.org/10.1016/j.sleep.2023.04.024
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