A Rare Case of PL-7-Associated Immune-Mediated Necrotizing Myopathy With Isolated Dysphagia as the Presenting Symptom

Immune-mediated necrotizing myopathy (IMNM) is a rare, progressive disease that accounts for about 19% of all inflammatory myopathies. Dysphagia occurs in about 20%-30% of IMNM patients. This case results in the third presumptive instance of IMNMwith dysphagia as the initial symptom. Given that isol...

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Autores principales: Khan, Tahir, Shareef, Aleeya, Shahid, Mohammad, Shabbir, Ehsan, Musleh, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163932/
https://www.ncbi.nlm.nih.gov/pubmed/37159795
http://dx.doi.org/10.7759/cureus.37215
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author Khan, Tahir
Shareef, Aleeya
Shahid, Mohammad
Shabbir, Ehsan
Musleh, Mustafa
author_facet Khan, Tahir
Shareef, Aleeya
Shahid, Mohammad
Shabbir, Ehsan
Musleh, Mustafa
author_sort Khan, Tahir
collection PubMed
description Immune-mediated necrotizing myopathy (IMNM) is a rare, progressive disease that accounts for about 19% of all inflammatory myopathies. Dysphagia occurs in about 20%-30% of IMNM patients. This case results in the third presumptive instance of IMNMwith dysphagia as the initial symptom. Given that isolated dysphagia in IMNM is atypical to the conventional symptoms in the late stage of the disease, it is critical for clinicians to have a high degree of suspicion for IMNM due to the aggressive nature of the disease and its refractoriness to treatment. Additionally, this case also highlights an atypical autoantibody, PL-7, being positive in an IMNM patient who presents with dysphagia as an initial symptom.
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spelling pubmed-101639322023-05-07 A Rare Case of PL-7-Associated Immune-Mediated Necrotizing Myopathy With Isolated Dysphagia as the Presenting Symptom Khan, Tahir Shareef, Aleeya Shahid, Mohammad Shabbir, Ehsan Musleh, Mustafa Cureus Internal Medicine Immune-mediated necrotizing myopathy (IMNM) is a rare, progressive disease that accounts for about 19% of all inflammatory myopathies. Dysphagia occurs in about 20%-30% of IMNM patients. This case results in the third presumptive instance of IMNMwith dysphagia as the initial symptom. Given that isolated dysphagia in IMNM is atypical to the conventional symptoms in the late stage of the disease, it is critical for clinicians to have a high degree of suspicion for IMNM due to the aggressive nature of the disease and its refractoriness to treatment. Additionally, this case also highlights an atypical autoantibody, PL-7, being positive in an IMNM patient who presents with dysphagia as an initial symptom. Cureus 2023-04-06 /pmc/articles/PMC10163932/ /pubmed/37159795 http://dx.doi.org/10.7759/cureus.37215 Text en Copyright © 2023, Khan et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Khan, Tahir
Shareef, Aleeya
Shahid, Mohammad
Shabbir, Ehsan
Musleh, Mustafa
A Rare Case of PL-7-Associated Immune-Mediated Necrotizing Myopathy With Isolated Dysphagia as the Presenting Symptom
title A Rare Case of PL-7-Associated Immune-Mediated Necrotizing Myopathy With Isolated Dysphagia as the Presenting Symptom
title_full A Rare Case of PL-7-Associated Immune-Mediated Necrotizing Myopathy With Isolated Dysphagia as the Presenting Symptom
title_fullStr A Rare Case of PL-7-Associated Immune-Mediated Necrotizing Myopathy With Isolated Dysphagia as the Presenting Symptom
title_full_unstemmed A Rare Case of PL-7-Associated Immune-Mediated Necrotizing Myopathy With Isolated Dysphagia as the Presenting Symptom
title_short A Rare Case of PL-7-Associated Immune-Mediated Necrotizing Myopathy With Isolated Dysphagia as the Presenting Symptom
title_sort rare case of pl-7-associated immune-mediated necrotizing myopathy with isolated dysphagia as the presenting symptom
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163932/
https://www.ncbi.nlm.nih.gov/pubmed/37159795
http://dx.doi.org/10.7759/cureus.37215
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