Cargando…

Post-discharge health assessment in survivors of coronavirus disease: a time-point analysis of a prospective cohort study

PURPOSE:  The objective of this study was to quantitatively evaluate psychological and quality of life-related complications at three months following discharge in hospitalized coronavirus disease 2019 (COVID-19) patients during the pandemic in Iran. METHODS: In this time-point analysis of prospecti...

Descripción completa

Detalles Bibliográficos
Autores principales: Sami, Ramin, Arabi, Sina, Ghasemi, Khojasteh, Akafzadeh, Mahsa, Ebrahimi, Sara, Toghyani, Arash, Mahvari, Razieh, Moayednia, Reza, Dadkhahi, Seyed Amir, Sadeghi, Sara, Marateb, Hamid Reza, Adibi, Peyman, Kavosh, Aryan, Mansourian, Marjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163985/
https://www.ncbi.nlm.nih.gov/pubmed/37149817
http://dx.doi.org/10.1007/s11136-023-03415-z
_version_ 1785037995511906304
author Sami, Ramin
Arabi, Sina
Ghasemi, Khojasteh
Akafzadeh, Mahsa
Ebrahimi, Sara
Toghyani, Arash
Mahvari, Razieh
Moayednia, Reza
Dadkhahi, Seyed Amir
Sadeghi, Sara
Marateb, Hamid Reza
Adibi, Peyman
Kavosh, Aryan
Mansourian, Marjan
author_facet Sami, Ramin
Arabi, Sina
Ghasemi, Khojasteh
Akafzadeh, Mahsa
Ebrahimi, Sara
Toghyani, Arash
Mahvari, Razieh
Moayednia, Reza
Dadkhahi, Seyed Amir
Sadeghi, Sara
Marateb, Hamid Reza
Adibi, Peyman
Kavosh, Aryan
Mansourian, Marjan
author_sort Sami, Ramin
collection PubMed
description PURPOSE:  The objective of this study was to quantitatively evaluate psychological and quality of life-related complications at three months following discharge in hospitalized coronavirus disease 2019 (COVID-19) patients during the pandemic in Iran. METHODS: In this time-point analysis of prospective cohort study data, adult patients hospitalized with symptoms suggestive of COVID-19 were enrolled. Patients were stratified in analyses based on severity. The primary outcomes consisted of psychological problems and pulmonary function tests (PFTs) in the three months following discharge, with Health-related quality of life (HRQoL) as the secondary outcome. Exploratory predictors were determined for both primary and secondary outcomes. RESULTS: 283 out of 900 (30%) eligible patients were accessible for the follow-up assessment and included in the study. The mean age was 53.65 ± 13.43 years, with 68% experiencing a severe disease course. At the time of the final follow-up, participants still reported persistent symptoms, among which fatigue, shortness of breath, and cough were the most common. Based on the regression-adjusted analysis, lower levels of forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) ratio was associated with higher levels of depression (standardized β = − 0.161 (SE = 0.042), P = 0.017) and stress levels (standardized β =− 0.110 (SE = 0.047), P = 0.015). Furthermore, higher levels of anti-SARS-CoV-2 immunoglobulin-M (IgM) were associated with significantly lower levels of depression (standardized β = − 0.139 (SE = 0.135), P = 0.031). CONCLUSIONS: There is an association between lung damage during COVID-19 and the reduction of pulmonary function for up to three months from acute infection in hospitalized patients. Varying degrees of anxiety, depression, stress, and low HRQoL frequently occur in patients with COVID-19. More severe lung damage and lower COVID-19 antibodies were associated with lower levels of psychological health. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11136-023-03415-z.
format Online
Article
Text
id pubmed-10163985
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-101639852023-05-09 Post-discharge health assessment in survivors of coronavirus disease: a time-point analysis of a prospective cohort study Sami, Ramin Arabi, Sina Ghasemi, Khojasteh Akafzadeh, Mahsa Ebrahimi, Sara Toghyani, Arash Mahvari, Razieh Moayednia, Reza Dadkhahi, Seyed Amir Sadeghi, Sara Marateb, Hamid Reza Adibi, Peyman Kavosh, Aryan Mansourian, Marjan Qual Life Res Article PURPOSE:  The objective of this study was to quantitatively evaluate psychological and quality of life-related complications at three months following discharge in hospitalized coronavirus disease 2019 (COVID-19) patients during the pandemic in Iran. METHODS: In this time-point analysis of prospective cohort study data, adult patients hospitalized with symptoms suggestive of COVID-19 were enrolled. Patients were stratified in analyses based on severity. The primary outcomes consisted of psychological problems and pulmonary function tests (PFTs) in the three months following discharge, with Health-related quality of life (HRQoL) as the secondary outcome. Exploratory predictors were determined for both primary and secondary outcomes. RESULTS: 283 out of 900 (30%) eligible patients were accessible for the follow-up assessment and included in the study. The mean age was 53.65 ± 13.43 years, with 68% experiencing a severe disease course. At the time of the final follow-up, participants still reported persistent symptoms, among which fatigue, shortness of breath, and cough were the most common. Based on the regression-adjusted analysis, lower levels of forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) ratio was associated with higher levels of depression (standardized β = − 0.161 (SE = 0.042), P = 0.017) and stress levels (standardized β =− 0.110 (SE = 0.047), P = 0.015). Furthermore, higher levels of anti-SARS-CoV-2 immunoglobulin-M (IgM) were associated with significantly lower levels of depression (standardized β = − 0.139 (SE = 0.135), P = 0.031). CONCLUSIONS: There is an association between lung damage during COVID-19 and the reduction of pulmonary function for up to three months from acute infection in hospitalized patients. Varying degrees of anxiety, depression, stress, and low HRQoL frequently occur in patients with COVID-19. More severe lung damage and lower COVID-19 antibodies were associated with lower levels of psychological health. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11136-023-03415-z. Springer International Publishing 2023-05-07 /pmc/articles/PMC10163985/ /pubmed/37149817 http://dx.doi.org/10.1007/s11136-023-03415-z Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Sami, Ramin
Arabi, Sina
Ghasemi, Khojasteh
Akafzadeh, Mahsa
Ebrahimi, Sara
Toghyani, Arash
Mahvari, Razieh
Moayednia, Reza
Dadkhahi, Seyed Amir
Sadeghi, Sara
Marateb, Hamid Reza
Adibi, Peyman
Kavosh, Aryan
Mansourian, Marjan
Post-discharge health assessment in survivors of coronavirus disease: a time-point analysis of a prospective cohort study
title Post-discharge health assessment in survivors of coronavirus disease: a time-point analysis of a prospective cohort study
title_full Post-discharge health assessment in survivors of coronavirus disease: a time-point analysis of a prospective cohort study
title_fullStr Post-discharge health assessment in survivors of coronavirus disease: a time-point analysis of a prospective cohort study
title_full_unstemmed Post-discharge health assessment in survivors of coronavirus disease: a time-point analysis of a prospective cohort study
title_short Post-discharge health assessment in survivors of coronavirus disease: a time-point analysis of a prospective cohort study
title_sort post-discharge health assessment in survivors of coronavirus disease: a time-point analysis of a prospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163985/
https://www.ncbi.nlm.nih.gov/pubmed/37149817
http://dx.doi.org/10.1007/s11136-023-03415-z
work_keys_str_mv AT samiramin postdischargehealthassessmentinsurvivorsofcoronavirusdiseaseatimepointanalysisofaprospectivecohortstudy
AT arabisina postdischargehealthassessmentinsurvivorsofcoronavirusdiseaseatimepointanalysisofaprospectivecohortstudy
AT ghasemikhojasteh postdischargehealthassessmentinsurvivorsofcoronavirusdiseaseatimepointanalysisofaprospectivecohortstudy
AT akafzadehmahsa postdischargehealthassessmentinsurvivorsofcoronavirusdiseaseatimepointanalysisofaprospectivecohortstudy
AT ebrahimisara postdischargehealthassessmentinsurvivorsofcoronavirusdiseaseatimepointanalysisofaprospectivecohortstudy
AT toghyaniarash postdischargehealthassessmentinsurvivorsofcoronavirusdiseaseatimepointanalysisofaprospectivecohortstudy
AT mahvarirazieh postdischargehealthassessmentinsurvivorsofcoronavirusdiseaseatimepointanalysisofaprospectivecohortstudy
AT moayedniareza postdischargehealthassessmentinsurvivorsofcoronavirusdiseaseatimepointanalysisofaprospectivecohortstudy
AT dadkhahiseyedamir postdischargehealthassessmentinsurvivorsofcoronavirusdiseaseatimepointanalysisofaprospectivecohortstudy
AT sadeghisara postdischargehealthassessmentinsurvivorsofcoronavirusdiseaseatimepointanalysisofaprospectivecohortstudy
AT maratebhamidreza postdischargehealthassessmentinsurvivorsofcoronavirusdiseaseatimepointanalysisofaprospectivecohortstudy
AT adibipeyman postdischargehealthassessmentinsurvivorsofcoronavirusdiseaseatimepointanalysisofaprospectivecohortstudy
AT kavosharyan postdischargehealthassessmentinsurvivorsofcoronavirusdiseaseatimepointanalysisofaprospectivecohortstudy
AT mansourianmarjan postdischargehealthassessmentinsurvivorsofcoronavirusdiseaseatimepointanalysisofaprospectivecohortstudy