The Selective NLRP3-inflammasome inhibitor MCC950 Mitigates Post-resuscitation Myocardial Dysfunction and Improves Survival in a Rat Model of Cardiac Arrest and Resuscitation

PURPOSE: To investigate the effects of the selective NLRP3 inflammasome inhibitor MCC950 on post-resuscitation myocardial function and survival in a rat model of cardiopulmonary resuscitation (CPR). METHODS: Thirty-six Sprague Dawley rats were randomized into three groups: (1) MCC950, (2) control, a...

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Detalles Bibliográficos
Autores principales: Zheng, Guanghui, He, Fenglian, Xu, Jing, Hu, Juntao, Ge, Weiwei, Ji, Xianfei, Wang, Changsheng, Bradley, Jennifer L., Peberdy, Mary Ann, Ornato, Joseph P., Jiang, Longyuan, Toldo, Stefano, Wang, Tong, Tang, Wanchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164003/
https://www.ncbi.nlm.nih.gov/pubmed/34973094
http://dx.doi.org/10.1007/s10557-021-07282-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164003/
https://www.ncbi.nlm.nih.gov/pubmed/34973094
http://dx.doi.org/10.1007/s10557-021-07282-z

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