Optimized metrics for orthogonal combinatorial CRISPR screens

CRISPR-based gene perturbation enables unbiased investigations of single and combinatorial genotype-to-phenotype associations. In light of efforts to map combinatorial gene dependencies at scale, choosing an efficient and robust CRISPR-associated (Cas) nuclease is of utmost importance. Even though S...

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Detalles Bibliográficos
Autores principales: Cetin, Ronay, Wegner, Martin, Luwisch, Leah, Saud, Sarada, Achmedov, Tatjana, Süsser, Sebastian, Vera-Guapi, Antonella, Müller, Konstantin, Matthess, Yves, Quandt, Eva, Schaubeck, Simone, Beisel, Chase L., Kaulich, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164157/
https://www.ncbi.nlm.nih.gov/pubmed/37149686
http://dx.doi.org/10.1038/s41598-023-34597-8

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