Reactivation of Parvovirus B19 Infection: An Uncommon Trigger of Macrophage Activation Syndrome in Adult-Onset Still’s Disease

A 40-year-old woman presented with four weeks of intermittent high-grade fever, cough, and joint pain, and two weeks of a generalized rash. She was found to have adult-onset Still’s disease (AOSD) and rapidly developed macrophage activation syndrome (MAS) on the second day of admission. Among infect...

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Detalles Bibliográficos
Autores principales: Leelaviwat, Natnicha, Armin, Sabiha, Mekraksakit, Poemlarp, Nugent, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164221/
https://www.ncbi.nlm.nih.gov/pubmed/37162784
http://dx.doi.org/10.7759/cureus.37231
Descripción
Sumario:A 40-year-old woman presented with four weeks of intermittent high-grade fever, cough, and joint pain, and two weeks of a generalized rash. She was found to have adult-onset Still’s disease (AOSD) and rapidly developed macrophage activation syndrome (MAS) on the second day of admission. Among infectious etiologies, Epstein-Barr virus and members of the herpes virus family are common triggers of MAS. However, our patient was found to have reactivation/recurrence of parvovirus B19 infection as the cause; this is an uncommon trigger reported infrequently in the medical literature. Despite intensive treatment, the patient passed away.

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