Reactivation of Parvovirus B19 Infection: An Uncommon Trigger of Macrophage Activation Syndrome in Adult-Onset Still’s Disease

A 40-year-old woman presented with four weeks of intermittent high-grade fever, cough, and joint pain, and two weeks of a generalized rash. She was found to have adult-onset Still’s disease (AOSD) and rapidly developed macrophage activation syndrome (MAS) on the second day of admission. Among infect...

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Autores principales: Leelaviwat, Natnicha, Armin, Sabiha, Mekraksakit, Poemlarp, Nugent, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164221/
https://www.ncbi.nlm.nih.gov/pubmed/37162784
http://dx.doi.org/10.7759/cureus.37231
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author Leelaviwat, Natnicha
Armin, Sabiha
Mekraksakit, Poemlarp
Nugent, Kenneth
author_facet Leelaviwat, Natnicha
Armin, Sabiha
Mekraksakit, Poemlarp
Nugent, Kenneth
author_sort Leelaviwat, Natnicha
collection PubMed
description A 40-year-old woman presented with four weeks of intermittent high-grade fever, cough, and joint pain, and two weeks of a generalized rash. She was found to have adult-onset Still’s disease (AOSD) and rapidly developed macrophage activation syndrome (MAS) on the second day of admission. Among infectious etiologies, Epstein-Barr virus and members of the herpes virus family are common triggers of MAS. However, our patient was found to have reactivation/recurrence of parvovirus B19 infection as the cause; this is an uncommon trigger reported infrequently in the medical literature. Despite intensive treatment, the patient passed away.
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spelling pubmed-101642212023-05-08 Reactivation of Parvovirus B19 Infection: An Uncommon Trigger of Macrophage Activation Syndrome in Adult-Onset Still’s Disease Leelaviwat, Natnicha Armin, Sabiha Mekraksakit, Poemlarp Nugent, Kenneth Cureus Internal Medicine A 40-year-old woman presented with four weeks of intermittent high-grade fever, cough, and joint pain, and two weeks of a generalized rash. She was found to have adult-onset Still’s disease (AOSD) and rapidly developed macrophage activation syndrome (MAS) on the second day of admission. Among infectious etiologies, Epstein-Barr virus and members of the herpes virus family are common triggers of MAS. However, our patient was found to have reactivation/recurrence of parvovirus B19 infection as the cause; this is an uncommon trigger reported infrequently in the medical literature. Despite intensive treatment, the patient passed away. Cureus 2023-04-06 /pmc/articles/PMC10164221/ /pubmed/37162784 http://dx.doi.org/10.7759/cureus.37231 Text en Copyright © 2023, Leelaviwat et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Leelaviwat, Natnicha
Armin, Sabiha
Mekraksakit, Poemlarp
Nugent, Kenneth
Reactivation of Parvovirus B19 Infection: An Uncommon Trigger of Macrophage Activation Syndrome in Adult-Onset Still’s Disease
title Reactivation of Parvovirus B19 Infection: An Uncommon Trigger of Macrophage Activation Syndrome in Adult-Onset Still’s Disease
title_full Reactivation of Parvovirus B19 Infection: An Uncommon Trigger of Macrophage Activation Syndrome in Adult-Onset Still’s Disease
title_fullStr Reactivation of Parvovirus B19 Infection: An Uncommon Trigger of Macrophage Activation Syndrome in Adult-Onset Still’s Disease
title_full_unstemmed Reactivation of Parvovirus B19 Infection: An Uncommon Trigger of Macrophage Activation Syndrome in Adult-Onset Still’s Disease
title_short Reactivation of Parvovirus B19 Infection: An Uncommon Trigger of Macrophage Activation Syndrome in Adult-Onset Still’s Disease
title_sort reactivation of parvovirus b19 infection: an uncommon trigger of macrophage activation syndrome in adult-onset still’s disease
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164221/
https://www.ncbi.nlm.nih.gov/pubmed/37162784
http://dx.doi.org/10.7759/cureus.37231
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