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Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes

INTRODUCTION: Young children with type 1 diabetes (T1D) may be at particularly high risk of cognitive decline following diabetic ketoacidosis (DKA). However, studies of cognitive functioning in T1D typically examine school‐age children. The goal of this study was to examine whether a single experien...

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Autores principales: Ghetti, Simona, Kuppermann, Nathan, Rewers, Arleta, Myers, Sage R., Schunk, Jeff E., Stoner, Michael J., Garro, Aris, Quayle, Kimberly S., Brown, Kathleen M., Trainor, Jennifer L., Tzimenatos, Leah, DePiero, Andrew D., McManemy, Julie K., Nigrovic, Lise E., Kwok, Maria Y., Olsen, Cody S., Casper, T. Charles, Glaser, Nicole S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164422/
https://www.ncbi.nlm.nih.gov/pubmed/36788736
http://dx.doi.org/10.1002/edm2.412
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author Ghetti, Simona
Kuppermann, Nathan
Rewers, Arleta
Myers, Sage R.
Schunk, Jeff E.
Stoner, Michael J.
Garro, Aris
Quayle, Kimberly S.
Brown, Kathleen M.
Trainor, Jennifer L.
Tzimenatos, Leah
DePiero, Andrew D.
McManemy, Julie K.
Nigrovic, Lise E.
Kwok, Maria Y.
Olsen, Cody S.
Casper, T. Charles
Glaser, Nicole S.
author_facet Ghetti, Simona
Kuppermann, Nathan
Rewers, Arleta
Myers, Sage R.
Schunk, Jeff E.
Stoner, Michael J.
Garro, Aris
Quayle, Kimberly S.
Brown, Kathleen M.
Trainor, Jennifer L.
Tzimenatos, Leah
DePiero, Andrew D.
McManemy, Julie K.
Nigrovic, Lise E.
Kwok, Maria Y.
Olsen, Cody S.
Casper, T. Charles
Glaser, Nicole S.
author_sort Ghetti, Simona
collection PubMed
description INTRODUCTION: Young children with type 1 diabetes (T1D) may be at particularly high risk of cognitive decline following diabetic ketoacidosis (DKA). However, studies of cognitive functioning in T1D typically examine school‐age children. The goal of this study was to examine whether a single experience of DKA is associated with lower cognitive functioning in young children. We found that recently diagnosed 3‐ to 5‐year‐olds who experienced one DKA episode, regardless of its severity, exhibited lower IQ scores than those with no DKA exposure. METHODS: We prospectively enrolled 46 3‐ to 5‐year‐old children, who presented with DKA at the onset of T1D, in a randomized multi‐site clinical trial evaluating intravenous fluid protocols for DKA treatment. DKA was moderate/severe in 22 children and mild in 24 children. Neurocognitive function was assessed once 2–6 months after the DKA episode. A comparison group of 27 children with T1D, but no DKA exposure, was also assessed. Patient groups were matched for age and T1D duration at the time of neurocognitive testing. RESULTS: Children who experienced DKA, regardless of its severity, exhibited significantly lower IQ scores than children who did not experience DKA, F(2, 70) = 6.26, p = .003, partial η (2) = .15. This effect persisted after accounting for socioeconomic status and ethnicity. CONCLUSIONS: A single DKA episode is associated with lower IQ scores soon after exposure to DKA in young children.
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spelling pubmed-101644222023-05-08 Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes Ghetti, Simona Kuppermann, Nathan Rewers, Arleta Myers, Sage R. Schunk, Jeff E. Stoner, Michael J. Garro, Aris Quayle, Kimberly S. Brown, Kathleen M. Trainor, Jennifer L. Tzimenatos, Leah DePiero, Andrew D. McManemy, Julie K. Nigrovic, Lise E. Kwok, Maria Y. Olsen, Cody S. Casper, T. Charles Glaser, Nicole S. Endocrinol Diabetes Metab Research Articles INTRODUCTION: Young children with type 1 diabetes (T1D) may be at particularly high risk of cognitive decline following diabetic ketoacidosis (DKA). However, studies of cognitive functioning in T1D typically examine school‐age children. The goal of this study was to examine whether a single experience of DKA is associated with lower cognitive functioning in young children. We found that recently diagnosed 3‐ to 5‐year‐olds who experienced one DKA episode, regardless of its severity, exhibited lower IQ scores than those with no DKA exposure. METHODS: We prospectively enrolled 46 3‐ to 5‐year‐old children, who presented with DKA at the onset of T1D, in a randomized multi‐site clinical trial evaluating intravenous fluid protocols for DKA treatment. DKA was moderate/severe in 22 children and mild in 24 children. Neurocognitive function was assessed once 2–6 months after the DKA episode. A comparison group of 27 children with T1D, but no DKA exposure, was also assessed. Patient groups were matched for age and T1D duration at the time of neurocognitive testing. RESULTS: Children who experienced DKA, regardless of its severity, exhibited significantly lower IQ scores than children who did not experience DKA, F(2, 70) = 6.26, p = .003, partial η (2) = .15. This effect persisted after accounting for socioeconomic status and ethnicity. CONCLUSIONS: A single DKA episode is associated with lower IQ scores soon after exposure to DKA in young children. John Wiley and Sons Inc. 2023-02-14 /pmc/articles/PMC10164422/ /pubmed/36788736 http://dx.doi.org/10.1002/edm2.412 Text en © 2023 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Ghetti, Simona
Kuppermann, Nathan
Rewers, Arleta
Myers, Sage R.
Schunk, Jeff E.
Stoner, Michael J.
Garro, Aris
Quayle, Kimberly S.
Brown, Kathleen M.
Trainor, Jennifer L.
Tzimenatos, Leah
DePiero, Andrew D.
McManemy, Julie K.
Nigrovic, Lise E.
Kwok, Maria Y.
Olsen, Cody S.
Casper, T. Charles
Glaser, Nicole S.
Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes
title Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes
title_full Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes
title_fullStr Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes
title_full_unstemmed Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes
title_short Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes
title_sort cognitive function following diabetic ketoacidosis in young children with type 1 diabetes
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164422/
https://www.ncbi.nlm.nih.gov/pubmed/36788736
http://dx.doi.org/10.1002/edm2.412
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