Single-cell individual full-length mtDNA sequencing by iMiGseq uncovers unexpected heteroplasmy shifts in mtDNA editing

The ontogeny and dynamics of mtDNA heteroplasmy remain unclear due to limitations of current mtDNA sequencing methods. We developed individual Mitochondrial Genome sequencing (iMiGseq) of full-length mtDNA for ultra-sensitive variant detection, complete haplotyping, and unbiased evaluation of hetero...

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Detalles Bibliográficos
Autores principales: Bi, Chongwei, Wang, Lin, Fan, Yong, Yuan, Baolei, Ramos-Mandujano, Gerardo, Zhang, Yingzi, Alsolami, Samhan, Zhou, Xuan, Wang, Jincheng, Shao, Yanjiao, Reddy, Pradeep, Zhang, Pu-Yao, Huang, Yanyi, Yu, Yang, Izpisua Belmonte, Juan Carlos, Li, Mo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164560/
https://www.ncbi.nlm.nih.gov/pubmed/36999592
http://dx.doi.org/10.1093/nar/gkad208

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