Genome manipulation by guide-directed Argonaute cleavage

Many prokaryotic argonautes (pAgos) mediate DNA interference by using small DNA guides to cleave target DNA. A recent study shows that CbAgo, a pAgo from Clostridium butyricum, induces DNA interference between homologous sequences and generates double-stranded breaks (DSBs) in target DNAs. This mech...

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Detalles Bibliográficos
Autores principales: Huang, Shan, Wang, Kaihang, Mayo, Stephen L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164581/
https://www.ncbi.nlm.nih.gov/pubmed/36928676
http://dx.doi.org/10.1093/nar/gkad188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164581/
https://www.ncbi.nlm.nih.gov/pubmed/36928676
http://dx.doi.org/10.1093/nar/gkad188

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