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Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting

Aims: The associations between low-density lipoprotein cholesterol (LDL-C) and the risk of cardiovascular disease (CVD) subtypes are not well established among the Japanese population. This study used longitudinal data from the Aichi Workers’ Cohort Study to explore the association between LDL-C lev...

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Autores principales: Al-shoaibi, Abubakr Ahmed Abdullah, Li, Yuanying, Song, Zean, Chiang, Chifa, Hirakawa, Yoshihisa, Saif-Ur-Rahman, KM, Shimoda, Masako, Nakano, Yoshihisa, Matsunaga, Masaaki, Aoyama, Atsuko, Tamakoshi, Koji, Ota, Atsuhiko, Yatsuya, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Atherosclerosis Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164596/
https://www.ncbi.nlm.nih.gov/pubmed/35831131
http://dx.doi.org/10.5551/jat.63519
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author Al-shoaibi, Abubakr Ahmed Abdullah
Li, Yuanying
Song, Zean
Chiang, Chifa
Hirakawa, Yoshihisa
Saif-Ur-Rahman, KM
Shimoda, Masako
Nakano, Yoshihisa
Matsunaga, Masaaki
Aoyama, Atsuko
Tamakoshi, Koji
Ota, Atsuhiko
Yatsuya, Hiroshi
author_facet Al-shoaibi, Abubakr Ahmed Abdullah
Li, Yuanying
Song, Zean
Chiang, Chifa
Hirakawa, Yoshihisa
Saif-Ur-Rahman, KM
Shimoda, Masako
Nakano, Yoshihisa
Matsunaga, Masaaki
Aoyama, Atsuko
Tamakoshi, Koji
Ota, Atsuhiko
Yatsuya, Hiroshi
author_sort Al-shoaibi, Abubakr Ahmed Abdullah
collection PubMed
description Aims: The associations between low-density lipoprotein cholesterol (LDL-C) and the risk of cardiovascular disease (CVD) subtypes are not well established among the Japanese population. This study used longitudinal data from the Aichi Workers’ Cohort Study to explore the association between LDL-C levels and the risk of coronary heart disease (CHD) and stroke subtypes. Methods: Pooled data of 8966 adults (7093men and 1903 women) who were recruited between (2002) and (2008) were used for the current analysis. Propensity scores for the LDL-C categories were generated using multinomial logistic regression. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from the inverse probability weighted Cox proportional hazards model for LDL-C category associations with risks of CHD, stroke subtypes, and CVD. Results: During a median follow-up of 12 years, 122 strokes (57 ischemic strokes, 25 intracerebral hemorrhage, and 40 unknown subtypes) and 82 cases of CHD were observed. LDL-C 160– mg/dL compared to LDL-C 100–119 mg/dL was positively and significantly associated with the risk of CHD (HR: 4.56; 95% CI: 1.91–10.9) but not with ischemic stroke (HR: 0.99; 95% CI: 0.44–2.22). LDL-C was inversely associated with the risk of intracerebral hemorrhage (P for trend=0.009). Conclusion: In middle-aged Japanese workers, LDL-C was significantly and positively associated with CHD, but not with ischemic stroke. LDL-C was inversely significantly associated with intracerebral hemorrhage.
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spelling pubmed-101645962023-05-09 Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting Al-shoaibi, Abubakr Ahmed Abdullah Li, Yuanying Song, Zean Chiang, Chifa Hirakawa, Yoshihisa Saif-Ur-Rahman, KM Shimoda, Masako Nakano, Yoshihisa Matsunaga, Masaaki Aoyama, Atsuko Tamakoshi, Koji Ota, Atsuhiko Yatsuya, Hiroshi J Atheroscler Thromb Original Article Aims: The associations between low-density lipoprotein cholesterol (LDL-C) and the risk of cardiovascular disease (CVD) subtypes are not well established among the Japanese population. This study used longitudinal data from the Aichi Workers’ Cohort Study to explore the association between LDL-C levels and the risk of coronary heart disease (CHD) and stroke subtypes. Methods: Pooled data of 8966 adults (7093men and 1903 women) who were recruited between (2002) and (2008) were used for the current analysis. Propensity scores for the LDL-C categories were generated using multinomial logistic regression. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from the inverse probability weighted Cox proportional hazards model for LDL-C category associations with risks of CHD, stroke subtypes, and CVD. Results: During a median follow-up of 12 years, 122 strokes (57 ischemic strokes, 25 intracerebral hemorrhage, and 40 unknown subtypes) and 82 cases of CHD were observed. LDL-C 160– mg/dL compared to LDL-C 100–119 mg/dL was positively and significantly associated with the risk of CHD (HR: 4.56; 95% CI: 1.91–10.9) but not with ischemic stroke (HR: 0.99; 95% CI: 0.44–2.22). LDL-C was inversely associated with the risk of intracerebral hemorrhage (P for trend=0.009). Conclusion: In middle-aged Japanese workers, LDL-C was significantly and positively associated with CHD, but not with ischemic stroke. LDL-C was inversely significantly associated with intracerebral hemorrhage. Japan Atherosclerosis Society 2023-05-01 2022-07-13 /pmc/articles/PMC10164596/ /pubmed/35831131 http://dx.doi.org/10.5551/jat.63519 Text en 2023 Japan Atherosclerosis Society https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/)
spellingShingle Original Article
Al-shoaibi, Abubakr Ahmed Abdullah
Li, Yuanying
Song, Zean
Chiang, Chifa
Hirakawa, Yoshihisa
Saif-Ur-Rahman, KM
Shimoda, Masako
Nakano, Yoshihisa
Matsunaga, Masaaki
Aoyama, Atsuko
Tamakoshi, Koji
Ota, Atsuhiko
Yatsuya, Hiroshi
Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting
title Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting
title_full Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting
title_fullStr Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting
title_full_unstemmed Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting
title_short Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting
title_sort association of low-density lipoprotein cholesterol with risk of coronary heart disease and stroke among middle-aged japanese workers: an analysis using inverse probability weighting
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164596/
https://www.ncbi.nlm.nih.gov/pubmed/35831131
http://dx.doi.org/10.5551/jat.63519
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