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Peptide aptamer targeting Aβ–PrP–Fyn axis reduces Alzheimer’s disease pathologies in 5XFAD transgenic mouse model

Currently, no effective therapeutics exist for the treatment of incurable neurodegenerative diseases such as Alzheimer’s disease (AD). The cellular prion protein (PrP(C)) acts as a high-affinity receptor for amyloid beta oligomers (AβO), a main neurotoxic species mediating AD pathology. The interact...

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Detalles Bibliográficos
Autores principales:	Ali, Tahir, Klein, Antonia N., Vu, Alex, Arifin, Maria I., Hannaoui, Samia, Gilch, Sabine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164677/ https://www.ncbi.nlm.nih.gov/pubmed/37149826 http://dx.doi.org/10.1007/s00018-023-04785-w

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