Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin

The γ-secretase complex catalyzes the intramembrane cleavage of C99, a carboxy-terminal fragment of the amyloid precursor protein. Two paralogs of its catalytic subunit presenilin (PS1 and PS2) are expressed which are autocatalytically cleaved into an N-terminal and a C-terminal fragment during matu...

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Detalles Bibliográficos
Autores principales: Schmidt, Fabian C., Fitz, Katja, Feilen, Lukas P., Okochi, Masayasu, Steiner, Harald, Langosch, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164903/
https://www.ncbi.nlm.nih.gov/pubmed/36944398
http://dx.doi.org/10.1016/j.jbc.2023.104626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164903/
https://www.ncbi.nlm.nih.gov/pubmed/36944398
http://dx.doi.org/10.1016/j.jbc.2023.104626

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