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Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin
The γ-secretase complex catalyzes the intramembrane cleavage of C99, a carboxy-terminal fragment of the amyloid precursor protein. Two paralogs of its catalytic subunit presenilin (PS1 and PS2) are expressed which are autocatalytically cleaved into an N-terminal and a C-terminal fragment during matu...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164903/ https://www.ncbi.nlm.nih.gov/pubmed/36944398 http://dx.doi.org/10.1016/j.jbc.2023.104626 |