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The characteristics of head and neck squamous cell cancer in young adults: A retrospective single-center study

We aimed to characterize clinical and prognostical factors of primary head and neck squamous cell carcinoma (HNSCC) in 85 young patients (≤39 years, median age: 37 years; between 2000–2018) in comparison with 140 institutional general HNSCC patients (median age: 61.5 years). The patient’s medical re...

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Autores principales: Révész, Mónika, Oberna, Ferenc, Slezák, András, Ferenczi, Örs, Kenessey, István, Takácsi-Nagy, Zoltán
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164923/
https://www.ncbi.nlm.nih.gov/pubmed/37168050
http://dx.doi.org/10.3389/pore.2023.1611123
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author Révész, Mónika
Oberna, Ferenc
Slezák, András
Ferenczi, Örs
Kenessey, István
Takácsi-Nagy, Zoltán
author_facet Révész, Mónika
Oberna, Ferenc
Slezák, András
Ferenczi, Örs
Kenessey, István
Takácsi-Nagy, Zoltán
author_sort Révész, Mónika
collection PubMed
description We aimed to characterize clinical and prognostical factors of primary head and neck squamous cell carcinoma (HNSCC) in 85 young patients (≤39 years, median age: 37 years; between 2000–2018) in comparison with 140 institutional general HNSCC patients (median age: 61.5 years). The patient’s medical records were collected from the institutional database. The prevalence of smoking and alcohol consumption (65.8% and 48.1%) in the young group exceeded the regional population average but was below the institutional (86.4% and 55%) general HNSCC patient population. Primary tumor sites in the group of young patients were as follows: oral cavity (56.4%), oropharynx (17.6%), hypopharynx (11.7%), and larynx (14.1%). Cumulative five-year overall survival was 44.2% in the young group, but significantly better with early T (T1-2 vs. T3-4: 52.6% vs. 26.7%; p = 0.0058) and N0 status (N0 vs. N+: 65.2% vs. 32.3%; p = 0.0013). Young age, abstinence, earlier stage and laryngeal tumor site might predict a better prognosis. The age distribution and the high prevalence of traditional risk factors among the young patients as well as the predominance of oral cavity tumor localization suggest that the early onset of tumor development could be originated from the premature failure of the intrinsic protective mechanisms.
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spelling pubmed-101649232023-05-09 The characteristics of head and neck squamous cell cancer in young adults: A retrospective single-center study Révész, Mónika Oberna, Ferenc Slezák, András Ferenczi, Örs Kenessey, István Takácsi-Nagy, Zoltán Pathol Oncol Res Pathology and Oncology Archive We aimed to characterize clinical and prognostical factors of primary head and neck squamous cell carcinoma (HNSCC) in 85 young patients (≤39 years, median age: 37 years; between 2000–2018) in comparison with 140 institutional general HNSCC patients (median age: 61.5 years). The patient’s medical records were collected from the institutional database. The prevalence of smoking and alcohol consumption (65.8% and 48.1%) in the young group exceeded the regional population average but was below the institutional (86.4% and 55%) general HNSCC patient population. Primary tumor sites in the group of young patients were as follows: oral cavity (56.4%), oropharynx (17.6%), hypopharynx (11.7%), and larynx (14.1%). Cumulative five-year overall survival was 44.2% in the young group, but significantly better with early T (T1-2 vs. T3-4: 52.6% vs. 26.7%; p = 0.0058) and N0 status (N0 vs. N+: 65.2% vs. 32.3%; p = 0.0013). Young age, abstinence, earlier stage and laryngeal tumor site might predict a better prognosis. The age distribution and the high prevalence of traditional risk factors among the young patients as well as the predominance of oral cavity tumor localization suggest that the early onset of tumor development could be originated from the premature failure of the intrinsic protective mechanisms. Frontiers Media S.A. 2023-04-24 /pmc/articles/PMC10164923/ /pubmed/37168050 http://dx.doi.org/10.3389/pore.2023.1611123 Text en Copyright © 2023 Révész, Oberna, Slezák, Ferenczi, Kenessey and Takácsi-Nagy. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pathology and Oncology Archive
Révész, Mónika
Oberna, Ferenc
Slezák, András
Ferenczi, Örs
Kenessey, István
Takácsi-Nagy, Zoltán
The characteristics of head and neck squamous cell cancer in young adults: A retrospective single-center study
title The characteristics of head and neck squamous cell cancer in young adults: A retrospective single-center study
title_full The characteristics of head and neck squamous cell cancer in young adults: A retrospective single-center study
title_fullStr The characteristics of head and neck squamous cell cancer in young adults: A retrospective single-center study
title_full_unstemmed The characteristics of head and neck squamous cell cancer in young adults: A retrospective single-center study
title_short The characteristics of head and neck squamous cell cancer in young adults: A retrospective single-center study
title_sort characteristics of head and neck squamous cell cancer in young adults: a retrospective single-center study
topic Pathology and Oncology Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164923/
https://www.ncbi.nlm.nih.gov/pubmed/37168050
http://dx.doi.org/10.3389/pore.2023.1611123
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