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Interaction of LARP4 to filamin A mechanosensing domain regulates cell migrations

Filamin A (FLNA) is an actin cross-linking protein that mediates mechanotransduction. Force-dependent conformational changes of FLNA molecule expose cryptic binding site of FLNA, allowing interaction with partners such as integrin, smoothelin, and fimbacin. Here, we identified La-related protein 4 (...

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Detalles Bibliográficos
Autores principales: Mao, Zhenfeng, Nakamura, Fumihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164935/
https://www.ncbi.nlm.nih.gov/pubmed/37169020
http://dx.doi.org/10.3389/fcell.2023.1152109