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Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy?

Molecular and cellular components of the tumor microenvironment are essential for cancer progression. The cellular element comprises cancer cells and heterogeneous populations of non-cancer cells that satisfy tumor needs. Immune, vascular, and mesenchymal cells provide the necessary factors to feed...

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Autores principales: Villegas-Pineda, Julio César, Ramírez-de-Arellano, Adrián, Bueno-Urquiza, Lesly Jazmín, Lizarazo-Taborda, Mélida del Rosario, Pereira-Suárez, Ana Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164963/
https://www.ncbi.nlm.nih.gov/pubmed/37168385
http://dx.doi.org/10.3389/fonc.2023.1106757
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author Villegas-Pineda, Julio César
Ramírez-de-Arellano, Adrián
Bueno-Urquiza, Lesly Jazmín
Lizarazo-Taborda, Mélida del Rosario
Pereira-Suárez, Ana Laura
author_facet Villegas-Pineda, Julio César
Ramírez-de-Arellano, Adrián
Bueno-Urquiza, Lesly Jazmín
Lizarazo-Taborda, Mélida del Rosario
Pereira-Suárez, Ana Laura
author_sort Villegas-Pineda, Julio César
collection PubMed
description Molecular and cellular components of the tumor microenvironment are essential for cancer progression. The cellular element comprises cancer cells and heterogeneous populations of non-cancer cells that satisfy tumor needs. Immune, vascular, and mesenchymal cells provide the necessary factors to feed the tumor mass, promote its development, and favor the spread of cancer cells from the primary site to adjacent and distant anatomical sites. Cancer-associated fibroblasts (CAFs) are mesenchymal cells that promote carcinogenesis and progression of various malignant neoplasms. CAFs act through the secretion of metalloproteinases, growth factors, cytokines, mitochondrial DNA, and non-coding RNAs, among other molecules. Over the last few years, the evidence on the leading role of CAFs in gynecological cancers has notably increased, placing them as the cornerstone of neoplastic processes. In this review, the recently reported findings regarding the promoting role that CAFs play in gynecological cancers, their potential use as therapeutic targets, and the new evidence suggesting that they could act as tumor suppressors are analyzed and discussed.
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spelling pubmed-101649632023-05-09 Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy? Villegas-Pineda, Julio César Ramírez-de-Arellano, Adrián Bueno-Urquiza, Lesly Jazmín Lizarazo-Taborda, Mélida del Rosario Pereira-Suárez, Ana Laura Front Oncol Oncology Molecular and cellular components of the tumor microenvironment are essential for cancer progression. The cellular element comprises cancer cells and heterogeneous populations of non-cancer cells that satisfy tumor needs. Immune, vascular, and mesenchymal cells provide the necessary factors to feed the tumor mass, promote its development, and favor the spread of cancer cells from the primary site to adjacent and distant anatomical sites. Cancer-associated fibroblasts (CAFs) are mesenchymal cells that promote carcinogenesis and progression of various malignant neoplasms. CAFs act through the secretion of metalloproteinases, growth factors, cytokines, mitochondrial DNA, and non-coding RNAs, among other molecules. Over the last few years, the evidence on the leading role of CAFs in gynecological cancers has notably increased, placing them as the cornerstone of neoplastic processes. In this review, the recently reported findings regarding the promoting role that CAFs play in gynecological cancers, their potential use as therapeutic targets, and the new evidence suggesting that they could act as tumor suppressors are analyzed and discussed. Frontiers Media S.A. 2023-04-24 /pmc/articles/PMC10164963/ /pubmed/37168385 http://dx.doi.org/10.3389/fonc.2023.1106757 Text en Copyright © 2023 Villegas-Pineda, Ramírez-de-Arellano, Bueno-Urquiza, Lizarazo-Taborda and Pereira-Suárez https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Villegas-Pineda, Julio César
Ramírez-de-Arellano, Adrián
Bueno-Urquiza, Lesly Jazmín
Lizarazo-Taborda, Mélida del Rosario
Pereira-Suárez, Ana Laura
Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy?
title Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy?
title_full Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy?
title_fullStr Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy?
title_full_unstemmed Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy?
title_short Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy?
title_sort cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy?
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164963/
https://www.ncbi.nlm.nih.gov/pubmed/37168385
http://dx.doi.org/10.3389/fonc.2023.1106757
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