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Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy?
Molecular and cellular components of the tumor microenvironment are essential for cancer progression. The cellular element comprises cancer cells and heterogeneous populations of non-cancer cells that satisfy tumor needs. Immune, vascular, and mesenchymal cells provide the necessary factors to feed...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164963/ https://www.ncbi.nlm.nih.gov/pubmed/37168385 http://dx.doi.org/10.3389/fonc.2023.1106757 |
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author | Villegas-Pineda, Julio César Ramírez-de-Arellano, Adrián Bueno-Urquiza, Lesly Jazmín Lizarazo-Taborda, Mélida del Rosario Pereira-Suárez, Ana Laura |
author_facet | Villegas-Pineda, Julio César Ramírez-de-Arellano, Adrián Bueno-Urquiza, Lesly Jazmín Lizarazo-Taborda, Mélida del Rosario Pereira-Suárez, Ana Laura |
author_sort | Villegas-Pineda, Julio César |
collection | PubMed |
description | Molecular and cellular components of the tumor microenvironment are essential for cancer progression. The cellular element comprises cancer cells and heterogeneous populations of non-cancer cells that satisfy tumor needs. Immune, vascular, and mesenchymal cells provide the necessary factors to feed the tumor mass, promote its development, and favor the spread of cancer cells from the primary site to adjacent and distant anatomical sites. Cancer-associated fibroblasts (CAFs) are mesenchymal cells that promote carcinogenesis and progression of various malignant neoplasms. CAFs act through the secretion of metalloproteinases, growth factors, cytokines, mitochondrial DNA, and non-coding RNAs, among other molecules. Over the last few years, the evidence on the leading role of CAFs in gynecological cancers has notably increased, placing them as the cornerstone of neoplastic processes. In this review, the recently reported findings regarding the promoting role that CAFs play in gynecological cancers, their potential use as therapeutic targets, and the new evidence suggesting that they could act as tumor suppressors are analyzed and discussed. |
format | Online Article Text |
id | pubmed-10164963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101649632023-05-09 Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy? Villegas-Pineda, Julio César Ramírez-de-Arellano, Adrián Bueno-Urquiza, Lesly Jazmín Lizarazo-Taborda, Mélida del Rosario Pereira-Suárez, Ana Laura Front Oncol Oncology Molecular and cellular components of the tumor microenvironment are essential for cancer progression. The cellular element comprises cancer cells and heterogeneous populations of non-cancer cells that satisfy tumor needs. Immune, vascular, and mesenchymal cells provide the necessary factors to feed the tumor mass, promote its development, and favor the spread of cancer cells from the primary site to adjacent and distant anatomical sites. Cancer-associated fibroblasts (CAFs) are mesenchymal cells that promote carcinogenesis and progression of various malignant neoplasms. CAFs act through the secretion of metalloproteinases, growth factors, cytokines, mitochondrial DNA, and non-coding RNAs, among other molecules. Over the last few years, the evidence on the leading role of CAFs in gynecological cancers has notably increased, placing them as the cornerstone of neoplastic processes. In this review, the recently reported findings regarding the promoting role that CAFs play in gynecological cancers, their potential use as therapeutic targets, and the new evidence suggesting that they could act as tumor suppressors are analyzed and discussed. Frontiers Media S.A. 2023-04-24 /pmc/articles/PMC10164963/ /pubmed/37168385 http://dx.doi.org/10.3389/fonc.2023.1106757 Text en Copyright © 2023 Villegas-Pineda, Ramírez-de-Arellano, Bueno-Urquiza, Lizarazo-Taborda and Pereira-Suárez https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Villegas-Pineda, Julio César Ramírez-de-Arellano, Adrián Bueno-Urquiza, Lesly Jazmín Lizarazo-Taborda, Mélida del Rosario Pereira-Suárez, Ana Laura Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy? |
title | Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy? |
title_full | Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy? |
title_fullStr | Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy? |
title_full_unstemmed | Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy? |
title_short | Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy? |
title_sort | cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy? |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164963/ https://www.ncbi.nlm.nih.gov/pubmed/37168385 http://dx.doi.org/10.3389/fonc.2023.1106757 |
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