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Reactivation of mutant p53 in esophageal squamous cell carcinoma by isothiocyanate inhibits tumor growth

p53 mutations are prevalent in human cancers; approximately half of patients with esophageal cancer present these mutations. Mutant p53 (mutp53) exerts oncogenic functions that promote malignant tumor progression, invasion, metastasis, and drug resistance, resulting in poor prognosis. Some small mol...

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Detalles Bibliográficos
Autores principales:	Guan, Lulu, Yang, Yalan, Lu, Yao, Chen, Yu, Luo, Xi, Xin, Dao, Meng, Xiangrui, Shan, Zhengzheng, Jiang, Guozhong, Wang, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164965/ https://www.ncbi.nlm.nih.gov/pubmed/37168998 http://dx.doi.org/10.3389/fphar.2023.1141420

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