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The effect of terminal impedance on aortic morphology and hemodynamics: an in vitro phantom study using flow field visualization
To investigate the risk factors for aortic dissection tearing, we fabricated a simplified patient-specific aortic silicone phantom using the brush-spin-coating method. The aortic phantom only includes the aorta from the ascending aorta to the descending aorta, without other branches. We designed two...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165012/ https://www.ncbi.nlm.nih.gov/pubmed/37168613 http://dx.doi.org/10.3389/fbioe.2023.1175916 |
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author | Chen, Huimin Wang, Wenjun Liu, Dengji Cao, Zhen Yang, Yi He, Ying Chi, Qingzhuo |
author_facet | Chen, Huimin Wang, Wenjun Liu, Dengji Cao, Zhen Yang, Yi He, Ying Chi, Qingzhuo |
author_sort | Chen, Huimin |
collection | PubMed |
description | To investigate the risk factors for aortic dissection tearing, we fabricated a simplified patient-specific aortic silicone phantom using the brush-spin-coating method. The aortic phantom only includes the aorta from the ascending aorta to the descending aorta, without other branches. We designed two experiments to investigate the alteration of aortic morphology and intravascular hemodynamics using the particle image velocimetry method. The results revealed dilation and elongation of the aortic phantom, especially the ascending aorta, after the phantom’s terminal resistance was increased. Additionally, the particle image velocimetry results demonstrated an increased vortex region, which caused the inner side of the aortic wall to become scoured by blood. This study suggests that the deformation of the inner side aortic wall and the change in hemodynamics in response to the increased terminal resistance may be a risk factor for aortic tearing and should be monitored. |
format | Online Article Text |
id | pubmed-10165012 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101650122023-05-09 The effect of terminal impedance on aortic morphology and hemodynamics: an in vitro phantom study using flow field visualization Chen, Huimin Wang, Wenjun Liu, Dengji Cao, Zhen Yang, Yi He, Ying Chi, Qingzhuo Front Bioeng Biotechnol Bioengineering and Biotechnology To investigate the risk factors for aortic dissection tearing, we fabricated a simplified patient-specific aortic silicone phantom using the brush-spin-coating method. The aortic phantom only includes the aorta from the ascending aorta to the descending aorta, without other branches. We designed two experiments to investigate the alteration of aortic morphology and intravascular hemodynamics using the particle image velocimetry method. The results revealed dilation and elongation of the aortic phantom, especially the ascending aorta, after the phantom’s terminal resistance was increased. Additionally, the particle image velocimetry results demonstrated an increased vortex region, which caused the inner side of the aortic wall to become scoured by blood. This study suggests that the deformation of the inner side aortic wall and the change in hemodynamics in response to the increased terminal resistance may be a risk factor for aortic tearing and should be monitored. Frontiers Media S.A. 2023-04-24 /pmc/articles/PMC10165012/ /pubmed/37168613 http://dx.doi.org/10.3389/fbioe.2023.1175916 Text en Copyright © 2023 Chen, Wang, Liu, Cao, Yang, He and Chi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Chen, Huimin Wang, Wenjun Liu, Dengji Cao, Zhen Yang, Yi He, Ying Chi, Qingzhuo The effect of terminal impedance on aortic morphology and hemodynamics: an in vitro phantom study using flow field visualization |
title | The effect of terminal impedance on aortic morphology and hemodynamics: an in vitro phantom study using flow field visualization |
title_full | The effect of terminal impedance on aortic morphology and hemodynamics: an in vitro phantom study using flow field visualization |
title_fullStr | The effect of terminal impedance on aortic morphology and hemodynamics: an in vitro phantom study using flow field visualization |
title_full_unstemmed | The effect of terminal impedance on aortic morphology and hemodynamics: an in vitro phantom study using flow field visualization |
title_short | The effect of terminal impedance on aortic morphology and hemodynamics: an in vitro phantom study using flow field visualization |
title_sort | effect of terminal impedance on aortic morphology and hemodynamics: an in vitro phantom study using flow field visualization |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165012/ https://www.ncbi.nlm.nih.gov/pubmed/37168613 http://dx.doi.org/10.3389/fbioe.2023.1175916 |
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