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Die Kämpfe únd schláchten—the struggles and battles of innate-like effector T lymphocytes with microbes
The large majority of lymphocytes belong to the adaptive immune system, which are made up of B2 B cells and the αβ T cells; these are the effectors in an adaptive immune response. A multitudinous group of lymphoid lineage cells does not fit the conventional lymphocyte paradigm; it is the unconventio...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165076/ https://www.ncbi.nlm.nih.gov/pubmed/37168859 http://dx.doi.org/10.3389/fimmu.2023.1117825 |
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author | Joyce, Sebastian Okoye, Gosife Donald Driver, John P. |
author_facet | Joyce, Sebastian Okoye, Gosife Donald Driver, John P. |
author_sort | Joyce, Sebastian |
collection | PubMed |
description | The large majority of lymphocytes belong to the adaptive immune system, which are made up of B2 B cells and the αβ T cells; these are the effectors in an adaptive immune response. A multitudinous group of lymphoid lineage cells does not fit the conventional lymphocyte paradigm; it is the unconventional lymphocytes. Unconventional lymphocytes—here called innate/innate-like lymphocytes, include those that express rearranged antigen receptor genes and those that do not. Even though the innate/innate-like lymphocytes express rearranged, adaptive antigen-specific receptors, they behave like innate immune cells, which allows them to integrate sensory signals from the innate immune system and relay that umwelt to downstream innate and adaptive effector responses. Here, we review natural killer T cells and mucosal-associated invariant T cells—two prototypic innate-like T lymphocytes, which sense their local environment and relay that umwelt to downstream innate and adaptive effector cells to actuate an appropriate host response that confers immunity to infectious agents. |
format | Online Article Text |
id | pubmed-10165076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101650762023-05-09 Die Kämpfe únd schláchten—the struggles and battles of innate-like effector T lymphocytes with microbes Joyce, Sebastian Okoye, Gosife Donald Driver, John P. Front Immunol Immunology The large majority of lymphocytes belong to the adaptive immune system, which are made up of B2 B cells and the αβ T cells; these are the effectors in an adaptive immune response. A multitudinous group of lymphoid lineage cells does not fit the conventional lymphocyte paradigm; it is the unconventional lymphocytes. Unconventional lymphocytes—here called innate/innate-like lymphocytes, include those that express rearranged antigen receptor genes and those that do not. Even though the innate/innate-like lymphocytes express rearranged, adaptive antigen-specific receptors, they behave like innate immune cells, which allows them to integrate sensory signals from the innate immune system and relay that umwelt to downstream innate and adaptive effector responses. Here, we review natural killer T cells and mucosal-associated invariant T cells—two prototypic innate-like T lymphocytes, which sense their local environment and relay that umwelt to downstream innate and adaptive effector cells to actuate an appropriate host response that confers immunity to infectious agents. Frontiers Media S.A. 2023-04-24 /pmc/articles/PMC10165076/ /pubmed/37168859 http://dx.doi.org/10.3389/fimmu.2023.1117825 Text en Copyright © 2023 Joyce, Okoye and Driver https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Joyce, Sebastian Okoye, Gosife Donald Driver, John P. Die Kämpfe únd schláchten—the struggles and battles of innate-like effector T lymphocytes with microbes |
title |
Die Kämpfe únd schláchten—the struggles and battles of innate-like effector T lymphocytes with microbes |
title_full |
Die Kämpfe únd schláchten—the struggles and battles of innate-like effector T lymphocytes with microbes |
title_fullStr |
Die Kämpfe únd schláchten—the struggles and battles of innate-like effector T lymphocytes with microbes |
title_full_unstemmed |
Die Kämpfe únd schláchten—the struggles and battles of innate-like effector T lymphocytes with microbes |
title_short |
Die Kämpfe únd schláchten—the struggles and battles of innate-like effector T lymphocytes with microbes |
title_sort | die kämpfe únd schláchten—the struggles and battles of innate-like effector t lymphocytes with microbes |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165076/ https://www.ncbi.nlm.nih.gov/pubmed/37168859 http://dx.doi.org/10.3389/fimmu.2023.1117825 |
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