A review of complex in vitro cell culture stressing the importance of fluid flow and illustrated by organ on a chip liver models

The translation of new technology from development into widespread commercial use is a complex and time-consuming process that requires significant investment. This review looks at some important market needs for more complex in vitro models, the technical difficulties that must be overcome, particu...

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Autor principal: Wilkinson, John Malcolm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165094/
https://www.ncbi.nlm.nih.gov/pubmed/37168660
http://dx.doi.org/10.3389/ftox.2023.1170193
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author Wilkinson, John Malcolm
author_facet Wilkinson, John Malcolm
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description The translation of new technology from development into widespread commercial use is a complex and time-consuming process that requires significant investment. This review looks at some important market needs for more complex in vitro models, the technical difficulties that must be overcome, particularly those connected with introducing fluid flow using microfluidics, and also illustrates the economic benefits of more accurate models for drug toxicity. Beyond the strong ethical arguments for replacing the use of animals in drug safety testing and medical research, the author believes that financial benefits of adopting the new in vitro technology are becoming clear and will drive the adoption by industry.
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spelling pubmed-101650942023-05-09 A review of complex in vitro cell culture stressing the importance of fluid flow and illustrated by organ on a chip liver models Wilkinson, John Malcolm Front Toxicol Toxicology The translation of new technology from development into widespread commercial use is a complex and time-consuming process that requires significant investment. This review looks at some important market needs for more complex in vitro models, the technical difficulties that must be overcome, particularly those connected with introducing fluid flow using microfluidics, and also illustrates the economic benefits of more accurate models for drug toxicity. Beyond the strong ethical arguments for replacing the use of animals in drug safety testing and medical research, the author believes that financial benefits of adopting the new in vitro technology are becoming clear and will drive the adoption by industry. Frontiers Media S.A. 2023-04-24 /pmc/articles/PMC10165094/ /pubmed/37168660 http://dx.doi.org/10.3389/ftox.2023.1170193 Text en Copyright © 2023 Wilkinson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Toxicology
Wilkinson, John Malcolm
A review of complex in vitro cell culture stressing the importance of fluid flow and illustrated by organ on a chip liver models
title A review of complex in vitro cell culture stressing the importance of fluid flow and illustrated by organ on a chip liver models
title_full A review of complex in vitro cell culture stressing the importance of fluid flow and illustrated by organ on a chip liver models
title_fullStr A review of complex in vitro cell culture stressing the importance of fluid flow and illustrated by organ on a chip liver models
title_full_unstemmed A review of complex in vitro cell culture stressing the importance of fluid flow and illustrated by organ on a chip liver models
title_short A review of complex in vitro cell culture stressing the importance of fluid flow and illustrated by organ on a chip liver models
title_sort review of complex in vitro cell culture stressing the importance of fluid flow and illustrated by organ on a chip liver models
topic Toxicology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165094/
https://www.ncbi.nlm.nih.gov/pubmed/37168660
http://dx.doi.org/10.3389/ftox.2023.1170193
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