Terminal bridging of siRNA duplex at the ribose 2′ position controls strand bias and target sequence preference

Small interfering RNA (siRNA) and short hairpin RNA (shRNA) are widely used as RNA interference (RNAi) reagents. Recently, truncated shRNAs that trigger RNAi in a Dicer-independent manner have been developed. We generated a novel class of RNAi reagent, designated enforced strand bias (ESB) RNA, in w...

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Detalles Bibliográficos
Autores principales: Shibata, Atsushi, Shirohzu, Hisao, Iwakami, Yusuke, Abe, Tomoaki, Emura, Chisato, Aoki, Eriko, Ohgi, Tadaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165404/
https://www.ncbi.nlm.nih.gov/pubmed/37168798
http://dx.doi.org/10.1016/j.omtn.2023.04.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165404/
https://www.ncbi.nlm.nih.gov/pubmed/37168798
http://dx.doi.org/10.1016/j.omtn.2023.04.013

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