Repression of CENP-A assembly in metaphase requires HJURP phosphorylation and inhibition by M18BP1

Centromeres are the foundation for mitotic kinetochore assembly and thus are essential for chromosome segregation. Centromeres are epigenetically defined by nucleosomes containing the histone H3 variant CENP-A. CENP-A nucleosome assembly is uncoupled from replication and occurs in G1, but how cells...

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Detalles Bibliográficos
Autores principales: Flores Servin, Julio C., Brown, Rachel R., Straight, Aaron F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165474/
https://www.ncbi.nlm.nih.gov/pubmed/37141119
http://dx.doi.org/10.1083/jcb.202110124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165474/
https://www.ncbi.nlm.nih.gov/pubmed/37141119
http://dx.doi.org/10.1083/jcb.202110124

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